Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.
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Neurodegeneration and microtubule dynamics: death by a thousand cutsNeuropathy- and myopathy-associated mutations in human small heat shock proteins: Characteristics and evolutionary history of the mutation sitesHSPB1 facilitates the formation of non-centrosomal microtubulesChaperonopathies: Spotlight on Hereditary Motor NeuropathiesCharcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilamentsHDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 MutationPhosphorylation-dependent subcellular localization of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in cultured hippocampal neuronsHSP70 regulates the function of mitotic centrosomesThe specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability.Overexpression of mutant HSP27 causes axonal neuropathy in mice.Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in miceTruncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress.Molecular genetics of charcot-marie-tooth disease: from genes to genomes.Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart diseaseHeat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extensionMolecular chaperones and proteostasis regulation during redox imbalance.Animal models and therapeutic prospects for Charcot-Marie-Tooth disease.Contribution of small heat shock proteins to muscle development and function.Charcot-Marie-Tooth disease and pathways to molecular based therapies.HSPB1 mutations causing hereditary neuropathy in humans disrupt non-cell autonomous protection of motor neurons.A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.BPAG1a and b associate with EB1 and EB3 and modulate vesicular transport, Golgi apparatus structure, and cell migration in C2.7 myoblasts.Small heat shock proteins in ageing and age-related diseases.Chaperones: needed for both the good times and the bad times.L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways.Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative diseaseCharcot-Marie-Tooth 2F: phenotypic presentation of the Arg136Leu HSP27 mutation in a multigenerational family.Microtubules, axonal transport, and neuropathy.Microtubule dynamics in the peripheral nervous system: A matter of balance.Molecular Chaperones in the Pathogenesis of Amyotrophic Lateral Sclerosis: The Role of HSPB1.Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases.Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.The functional roles of the unstructured N- and C-terminal regions in αB-crystallin and other mammalian small heat-shock proteins.HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.
P2860
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P2860
Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@en
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@nl
type
label
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@en
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@nl
prefLabel
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@en
Small heat-shock protein HSPB1 ...... harcot-Marie-Tooth neuropathy.
@nl
P2093
P50
P1476
Small heat-shock protein HSPB1 ...... Charcot-Marie-Tooth neuropathy
@en
P2093
Abdelkrim Azmi
Constantin d'Ydewalle
Han Remaut
Kris Gevaert
Kristof Moonens
Sofie Goethals
Sophie Janssens
Vicky de Winter
Vincent Timmerman
P304
15320-15328
P356
10.1523/JNEUROSCI.3266-11.2011
P407
P577
2011-10-01T00:00:00Z