about
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathwaysThe histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolismA role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagyThe first identification of lysine malonylation substrates and its regulatory enzymeSIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body productionStructure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesInterplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingC. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stressMice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.The NAD-dependent deacetylase SIRT2 is required for programmed necrosisSIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylationSIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicityTelomere shortening exposes functions for the mouse Werner and Bloom syndrome genesDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsMammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationEssential role of limiting telomeres in the pathogenesis of Werner syndromeLeaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient miceNeural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.Sirtuins: guardians of mammalian healthspan.Ageing: longevity hits a roadblock.DNA repair, genome stability, and aging.Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.Mitochondrial sirtuins and their relationships with metabolic disease and cancer.The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samplesSIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylasesSIRT3: as simple as it seems?Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.Mass spectrometry-based detection of protein acetylation.Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.Calorie restriction alters mitochondrial protein acetylation.Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.Acetyl-ed question in mitochondrial biology?
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P50
description
hulumtues
@sq
researcher
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wetenschapper
@nl
հետազոտող
@hy
name
David B Lombard
@nl
David B Lombard
@sl
David B. Lombard
@en
David B. Lombard
@es
type
label
David B Lombard
@nl
David B Lombard
@sl
David B. Lombard
@en
David B. Lombard
@es
prefLabel
David B Lombard
@nl
David B Lombard
@sl
David B. Lombard
@en
David B. Lombard
@es
P106
P1153
26642952300
P21
P31
P496
0000-0002-4292-0185