Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
about
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyRoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingIn vivo veritas: using yeast to probe the biological functions of G-quadruplexesHuman premature aging, DNA repair and RecQ helicasesEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.trt-1 is the Caenorhabditis elegans catalytic subunit of telomerase.Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerAxis of ageing: telomeres, p53 and mitochondriaTelomere shortening in human diseasesEvidence that a RecQ helicase slows senescence by resolving recombining telomeresThe germline/soma dichotomy: implications for aging and degenerative diseaseTelomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene lociWRN loss induces switching of telomerase-independent mechanisms of telomere elongationThe DNA structure and sequence preferences of WRN underlie its function in telomeric recombination eventsBLM helicase facilitates telomere replication during leading strand synthesis of telomeresTelomeres and human disease: ageing, cancer and beyondExpression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicaseTelomerase deficiency affects the formation of chromosomal translocations by homologous recombination in Saccharomyces cerevisiae.Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.Distinct roles of RECQ1 in the maintenance of genomic stability.Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationHydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cellsComparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease.Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2The HRDC domain of BLM is required for the dissolution of double Holliday junctionsThe Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsSenescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.Acetylation of Werner syndrome protein (WRN): relationships with DNA damage, DNA replication and DNA metabolic activities.G-quadruplex nucleic acids and human diseaseElevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.Werner protein protects nonproliferating cells from oxidative DNA damage
P2860
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P2860
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
description
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Oktober 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/10/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/10/01)
@nl
наукова стаття, опублікована в жовтні 2004
@uk
مقالة علمية (نشرت في أكتوبر 2004)
@ar
name
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@ast
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@en
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@nl
type
label
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@ast
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@en
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@nl
prefLabel
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@ast
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@en
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@nl
P2093
P2860
P3181
P1476
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes
@en
P2093
Catherine Cheung
Emma E Furth
F Brad Johnson
Guangbin Luo
Johnny Shen
Leonard Guarente
Nishan Kugan
Robert J Pignolo
Ronald A DePinho
P2860
P304
P3181
P356
10.1128/MCB.24.19.8437-8446.2004
P407
P577
2004-10-01T00:00:00Z