Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.
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Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta poresElevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneusGanglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease miceCross-talk of membrane lipids and Alzheimer-related proteins.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic miceIntracranial V. cholerae sialidase protects against excitotoxic neurodegenerationGanglioside metabolism in a transgenic mouse model of Alzheimer's disease: expression of Chol-1α antigens in the brain.Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse modelsThe pathological roles of ganglioside metabolism in Alzheimer's disease: effects of gangliosides on neurogenesis.Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits.Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics.Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analoguesLinking lipids to Alzheimer's disease: cholesterol and beyond.Effects of membrane lipids on the activity and processivity of purified γ-secretaseRole of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a reviewBrain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aαComprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's diseaseAntioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice.Functional roles of gangliosides in neurodevelopment: an overview of recent advances.Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction.APP Function and Lipids: A Bidirectional Link.Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice.Structures, biosynthesis, and functions of gangliosides--an overview.The role of APP proteolytic processing in lipid metabolism.Implications for the mammalian sialidases in the physiopathology of skeletal muscleEndo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Omega-3 fatty acids, lipids and apoE lipidation in Alzheimer's disease: a rationale for multi-nutrient dementia prevention.Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells.GD3 accumulation in cell surface lipid rafts prior to mitochondrial targeting contributes to amyloid-β-induced apoptosis.Candidate genes in ocular dominance plasticityExpression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processingCharacterization of AD-like phenotype in aged APPSwe/PS1dE9 mice.Histone acetylation-mediated glycosyltransferase gene regulation in mouse brain during development.Effects of amyloid β-peptides and gangliosides on mouse neural stem cells.Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks.Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.
P2860
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P2860
Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@en
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@nl
type
label
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@en
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@nl
prefLabel
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@en
Elimination of GD3 synthase im ...... laque load in transgenic mice.
@nl
P2093
P50
P1476
Elimination of GD3 synthase im ...... plaque load in transgenic mice
@en
P2093
Aleksandra Bruchey
Alexandra Bernardo
Jiali Zhao
L Jackson Roberts
Meghan McCord
Rebecca Thompson
Robert K Yu
Sean S Davies
Toshio Ariga
Yasuji Matsuoka
P304
P356
10.1016/J.NEUROBIOLAGING.2007.12.022
P577
2008-02-06T00:00:00Z