Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines.
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Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5AIdentification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential displayComplex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursorMolecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag informationPosttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modificationThe post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NADExcess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosisEukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injuryThe role of polyamines in protein-dependent hypoxic tolerance of Drosophila.Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy.Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.The role of polyamines in supporting growth of mammalian cells is mediated through their requirement for translation initiation and elongationInhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.Impact of the antiproliferative agent ciclopirox olamine treatment on stem cells proteomeCryptosporidium parvum has an active hypusine biosynthesis pathway.Expression of eukaryotic initiation factor 5A and hypusine forming enzymes in glioblastoma patient samples: implications for new targeted therapiesDifferential expression of eIF5A-1 and eIF5A-2 in human cancer cells.Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.Assay of deoxyhypusine synthase activityAssay of deoxyhypusine hydroxylase activity.Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor.Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologsEIF3 p170, a mediator of mimosine effect on protein synthesis and cell cycle progression.An intercellular polyamine transfer via gap junctions regulates proliferation and response to stress in epithelial cells.Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication.The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2.eIF5A2 is an alternative pathway for cell proliferation in cetuximab-treated epithelial hepatocellular carcinoma.Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening.Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane.Polyamines and Their Role in Virus Infection.Independent roles of eIF5A and polyamines in cell proliferation.Interferon alpha2 recombinant and epidermal growth factor modulate proliferation and hypusine synthesis in human epidermoid cancer KB cells.The Essential Role of Spermidine in Growth of Agrobacterium tumefaciens Is Determined by the 1,3-Diaminopropane MoietyFlux control exerted by overt carnitine palmitoyltransferase over palmitoyl-CoA oxidation and ketogenesis is lower in suckling than in adult rats.Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
P2860
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P2860
Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Features of the spermidine-bin ...... lated diamines and polyamines.
@en
Features of the spermidine-bin ...... lated diamines and polyamines.
@nl
type
label
Features of the spermidine-bin ...... lated diamines and polyamines.
@en
Features of the spermidine-bin ...... lated diamines and polyamines.
@nl
prefLabel
Features of the spermidine-bin ...... lated diamines and polyamines.
@en
Features of the spermidine-bin ...... lated diamines and polyamines.
@nl
P2093
P1476
Features of the spermidine-bin ...... lated diamines and polyamines.
@en
P2093
P304
13151-13159
P407
P577
1993-06-01T00:00:00Z