The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)
about
Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5APosttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modificationMutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modificationSerine, glycine and one-carbon units: cancer metabolism in full circleCrystal Structure of Human Spermine Synthase: IMPLICATIONS OF SUBSTRATE BINDING AND CATALYTIC MECHANISMPoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella entericaA paralog of lysyl-tRNA synthetase aminoacylates a conserved lysine residue in translation elongation factor PModulation of protein synthesis by polyaminesNeisseria meningitidis Translation Elongation Factor P and Its Active-Site Arginine Residue Are Essential for Cell ViabilityComparative Proteomic and Physiological Analysis Reveals the Variation Mechanisms of Leaf Coloration and Carbon Fixation in a Xantha Mutant of Ginkgo biloba LFunctional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.The role of polyamines in protein-dependent hypoxic tolerance of Drosophila.Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species.Biochemical quantitation of the eIF5A hypusination in Arabidopsis thaliana uncovers ABA-dependent regulationFunctional significance of eIF5A and its hypusine modification in eukaryotesEvidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.Polyamines: ubiquitous polycations with unique roles in growth and stress responses.Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells.Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients.Cofactor biosynthesis through protein post-translational modification.The hypusine-containing translation factor eIF5A.A tumour suppressor network relying on the polyamine-hypusine axis.Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).Genome-wide analyses and functional classification of proline repeat-rich proteins: potential role of eIF5A in eukaryotic evolutionDifferential expression of eIF5A-1 and eIF5A-2 in human cancer cells.The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancerProduction of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.The deoxyhypusine synthase mutant dys1-1 reveals the association of eIF5A and Asc1 with cell wall integrity.Bulk segregant analysis followed by high-throughput sequencing reveals the Neurospora cell cycle gene, ndc-1, to be allelic with the gene for ornithine decarboxylase, spe-1A prolonged and exaggerated wound response with elevated ODC activity mimics early tumor development.Assay of deoxyhypusine synthase activityAssay of deoxyhypusine hydroxylase activity.Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
P2860
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P2860
The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@ast
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@en
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@nl
type
label
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@ast
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@en
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@nl
prefLabel
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@ast
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@en
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@nl
P2860
P3181
P356
P1476
The post-translational synthes ...... n initiation factor 5A (eIF5A)
@en
P2093
Myung Hee Park
P2860
P3181
P356
10.1093/JB/MVJ034
P407
P577
2006-02-01T00:00:00Z