Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
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Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to 20S proteasomal degradation of p63 resulting in thinning of epithelium and chemical-induced skin cancerIn Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF- B SignalingBeta-lapachone suppresses radiation-induced activation of nuclear factor-kappaBRelationships between metabolic and non-metabolic susceptibility factors in benzene toxicity.NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion.p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation.Genetic evidence for NAD(P)H:quinone oxidoreductase 1-catalyzed quinone reduction on passage through the mouse pulmonary circulation.Crosstalk of reactive oxygen species and NF-κB signalingA network model for angiogenesis in ovarian cancer.NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence.The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasiaTumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival.Preferential utilization of NADPH as the endogenous electron donor for NAD(P)H:quinone oxidoreductase 1 (NQO1) in intact pulmonary arterial endothelial cells.Hexosamine template. A platform for modulating gene expression and for sugar-based drug discoveryEffects of 10 cigarette smoke condensates on primary human airway epithelial cells by comparative gene and cytokine expression studies.DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis.Stress-induced NQO1 controls stability of C/EBPα against 20S proteasomal degradation to regulate p63 expression with implications in protection against chemical-induced skin cancer.CO/HO-1 Induces NQO-1 Expression via Nrf2 Activation.A metal carbonyl-protein needle composite designed for intracellular CO delivery to modulate NF-κB activity.Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function.Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.Effects of quercetin and catechin on hepatic glutathione-S transferase (GST), NAD(P)H quinone oxidoreductase 1 (NQO1), and antioxidant enzyme activity levels in rats.NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.Albumin-stimulated DNA synthesis is mediated by Ca2+/PKC as well as EGF receptor-dependent p44/42 MAPK and NF-kappaB signal pathways in renal proximal tubule cells.A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson's Disease Models.NQO1 expression correlates inversely with NFκB activation in human breast cancer
P2860
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P2860
Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@en
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@nl
type
label
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@en
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@nl
prefLabel
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@en
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@nl
P2093
P2860
P356
P1476
Genetic deletion of NAD(P)H:qu ...... ses and potentiates apoptosis.
@en
P2093
Anil K Jaiswal
Bharat B Aggarwal
Kwang Seok Ahn
P2860
P304
19798-19808
P356
10.1074/JBC.M601162200
P407
P577
2006-05-08T00:00:00Z