DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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2018 nî lūn-bûn

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.

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P1476

DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1

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P2093

Nathaniel R Landau

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SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

Double strand break repair functions of histone H2AX

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

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4153

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scholarly article

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10.1038/S41598-018-22432-4

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English

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Paula Jáuregui

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2018-03-07T00:00:00Z

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29515139

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5841438

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