about
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease.Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia.The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy.In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal StudiesShifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritisMicrobiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.Mouse and human neutrophils induce anaphylaxis.Shaping mycolactone for therapeutic use against inflammatory disorders.Autonomous phagosomal degradation and antigen presentation in dendritic cells.Regulation of allergy by Fc receptors.Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasitesNeutrophils mediate antibody-induced antitumor effects in mice.Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions.The function of Fcγ receptors in dendritic cells and macrophages.Mouse and human FcR effector functions.IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis.Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models.Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide.Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation.Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells.Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms.Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation.IgG subclasses determine pathways of anaphylaxis in mice.Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions.Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring.Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis.Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice.Inhibitory IgG Receptor-Expressing Cells: The Must-Have Accessory for Anti-CD40 Immunomodulatory mAb Efficacy.Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART.A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropeniaHuman IgG1 antibodies suppress angiogenesis in a target-independent mannerAn Engineered Human Fc variant With Exquisite Selectivity for FcγRIIIa Reveals That Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis With GM-CSF-Differentiated MacrophagesMutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling
P50
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Pierre Bruhns
@ast
Pierre Bruhns
@en
Pierre Bruhns
@es
Pierre Bruhns
@nl
type
label
Pierre Bruhns
@ast
Pierre Bruhns
@en
Pierre Bruhns
@es
Pierre Bruhns
@nl
prefLabel
Pierre Bruhns
@ast
Pierre Bruhns
@en
Pierre Bruhns
@es
Pierre Bruhns
@nl
P108
P106
P31
P496
0000-0002-4709-8936