The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
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DAXX is a new AIRE-interacting proteinA phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.Histone recognition and large-scale structural analysis of the human bromodomain familyStructure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulatorTRIM24 links a non-canonical histone signature to breast cancerDeaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetesRecognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF)Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3bAire and T cell developmentTranscriptional regulation by AIRE: molecular mechanisms of central toleranceThe Thymic Orchestration Involving Aire, miRNAs, and Cell-Cell Interactions during the Induction of Central ToleranceOvarian autoimmune disease: clinical concepts and animal modelsThe solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylationThe PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactomeNovel Findings into AIRE Genetics and Functioning: Clinical ImplicationsChd5 requires PHD-mediated histone 3 binding for tumor suppressionPHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains.Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modificationsCombinatorial profiling of chromatin binding modules reveals multisite discrimination.Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells.Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.PHD fingers: epigenetic effectors and potential drug targetsThe JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylationGlobal relevance of Aire binding to hypomethylated lysine-4 of histone-3.Control of central and peripheral tolerance by Aire.The PHD finger: a versatile epigenome reader.Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells.Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesisAPECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility FactorsClues to immune tolerance: the monogenic autoimmune syndromesBoth polymorphic variable number of tandem repeats and autoimmune regulator modulate differential expression of insulin in human thymic epithelial cells.Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.Readers of histone modifications.Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.Handpicking epigenetic marks with PHD fingers.
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The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression
description
article
@en
im Februar 2008 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2008
@uk
name
The autoimmune regulator PHD f ...... K4 to activate gene expression
@en
The autoimmune regulator PHD f ...... K4 to activate gene expression
@nl
type
label
The autoimmune regulator PHD f ...... K4 to activate gene expression
@en
The autoimmune regulator PHD f ...... K4 to activate gene expression
@nl
prefLabel
The autoimmune regulator PHD f ...... K4 to activate gene expression
@en
The autoimmune regulator PHD f ...... K4 to activate gene expression
@nl
P2093
P2860
P356
P1433
P1476
The autoimmune regulator PHD f ...... K4 to activate gene expression
@en
P2093
Ana Rebane
Csaba Hetényi
Francesca Chignola
Giovanna Musco
Ingrid Liiv
Luca Mollica
Matthew J Bottomley
Pärt Peterson
P2860
P304
P356
10.1038/SJ.EMBOR.2008.11
P577
2008-02-22T00:00:00Z