Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

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Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation

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im Januar 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 17 October 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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name

Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

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Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

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Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

@en

Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

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Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

@en

Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

@nl

P1476

Haploinsufficiency of A20 impa ...... NLRP3 inflammasome activation

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P2093

Airi Jartti

http://www.w3.org/2001/XMLSchema#string

Antti Väänänen

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Dan C Nordström

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Kari K Eklund

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Luca Trotta

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Nina Hautala

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Outi Kuismin

http://www.w3.org/2001/XMLSchema#string

Paula Keskitalo

http://www.w3.org/2001/XMLSchema#string

Paula Vähäsalo

http://www.w3.org/2001/XMLSchema#string

Päivi Jackson

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P2860

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

Converging roles of caspases in inflammasome activation, cell death and innate immunity

The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

UCSF Chimera--a visualization system for exploratory research and analysis

The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis

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e000740

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scholarly article

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10.1136/RMDOPEN-2018-000740

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English

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P478

http://www.w3.org/2001/XMLSchema#string

P50

P577

2018-10-17T00:00:00Z

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30402268

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P921

inflammasome

haploinsufficiency

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6203104

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