Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation

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Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation

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im September 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 06 September 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у вересні 2018

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Fumarate hydratase loss promot ...... amage after ionising radiation

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Fumarate hydratase loss promot ...... amage after ionising radiation

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Fumarate hydratase loss promot ...... amage after ionising radiation

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Fumarate hydratase loss promot ...... amage after ionising radiation

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Fumarate hydratase loss promot ...... amage after ionising radiation

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Fumarate hydratase loss promot ...... amage after ionising radiation

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P1476

Fumarate hydratase loss promot ...... amage after ionising radiation

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Ashley N Ferguson

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Timothy I Johnson

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Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

Oxidative DNA damage: mechanisms, mutation, and disease

Playing the end game: DNA double-strand break repair pathway choice

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Replication stress induces 53BP1-containing OPT domains in G1 cells.

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

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913

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scholarly article

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10.1038/S41419-018-0912-3

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English

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Christian Frezza

Ana S.H. Costa

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2018-09-06T00:00:00Z

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30190474

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immunology

cancer research

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6127199

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