Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities
about
Binding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseBioactivity guided fractionation of leaves extract of Nyctanthes arbor tristis (Harshringar) against P falciparum.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Molecular recognition in chemical and biological systems.Identification of potential trypanothione reductase inhibitors among commercially available [Formula: see text]-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.High throughput screening against the peroxidase cascade of African trypanosomes identifies antiparasitic compounds that inactivate tryparedoxin.Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.
P2860
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P2860
Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities
description
im Dezember 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 16 December 2010
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2010
@uk
name
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@en
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@nl
type
label
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@en
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@nl
prefLabel
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@en
Improved Inhibitors of Trypano ...... , and Antiprotozoal Activities
@nl
P2093
P2860
P356
P1433
P1476
Improved inhibitors of trypano ...... , and antiprotozoal activities
@en
P2093
Birgit Sophia Lauber
Christian Eberle
François Diederich
R Luise Krauth-Siegel
P2860
P304
P356
10.1002/CMDC.201000420
P577
2010-12-16T00:00:00Z