Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design
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Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein CrystallographyBinding to large enzyme pockets: small-molecule inhibitors of trypanothione reductaseThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsMachine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug DiscoveryOpportunities and Challenges in Antiparasitic Drug DiscoveryDiscovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.Huprines as a new family of dual acting trypanocidal-antiplasmodial agentsThe synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductaseTrypanocidal drugs: mechanisms, resistance and new targets.Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Thioredoxin reductase and its inhibitors.Molecular recognition in chemical and biological systems.Identification of potential trypanothione reductase inhibitors among commercially available [Formula: see text]-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.Novel aryl β-aminocarbonyl derivatives as inhibitors of Trypanosoma cruzi trypanothione reductase: binding mode revised by docking and GRIND2-based 3D-QSAR procedures.Biophysical insight into the heparin-peptide interaction and its modulation by a small molecule.Reactivity of 9-aminoacridine drug quinacrine with glutathione limits its antiprion activity.Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite.Improved Inhibitors of Trypanothione Reductase by Combination of Motifs: Synthesis, Inhibitory Potency, Binding Mode, and Antiprotozoal Activities
P2860
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P2860
Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design
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2004 nî lūn-bûn
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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年學術文章
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Two interacting binding sites ...... se: a template for drug design
@ast
Two interacting binding sites ...... se: a template for drug design
@en
Two interacting binding sites ...... se: a template for drug design
@nl
type
label
Two interacting binding sites ...... se: a template for drug design
@ast
Two interacting binding sites ...... se: a template for drug design
@en
Two interacting binding sites ...... se: a template for drug design
@nl
prefLabel
Two interacting binding sites ...... se: a template for drug design
@ast
Two interacting binding sites ...... se: a template for drug design
@en
Two interacting binding sites ...... se: a template for drug design
@nl
P2093
P2860
P50
P356
P1476
Two interacting binding sites ...... se: a template for drug design
@en
P2093
Ahilan Saravanamuthu
Mark R Peterson
William N Hunter
P2860
P304
P356
10.1074/JBC.M403187200
P407
P577
2004-07-09T00:00:00Z