about
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complexWLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidificationPsammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivativesCarteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.Origins of the specificity of tissue-type plasminogen activatorModulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase.Wnt signaling in development, disease and translational medicine.Binding of nonphysiological protein and peptide substrates to proteases: differences between urokinase-type plasminogen activator and trypsin and contributions to the evolution of regulated proteolysis.Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator.Negative selectivity and the evolution of protease cascades: the specificity of plasmin for peptide and protein substratesDistinct mechanisms contribute to stringent substrate specificity of tissue-type plasminogen activatorSubstrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen
P50
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P50
description
researcher ORCID ID = 0000-0002-0711-185X
@en
wetenschapper
@nl
name
Gary S Coombs
@ast
Gary S Coombs
@en
Gary S Coombs
@es
Gary S Coombs
@nl
type
label
Gary S Coombs
@ast
Gary S Coombs
@en
Gary S Coombs
@es
Gary S Coombs
@nl
prefLabel
Gary S Coombs
@ast
Gary S Coombs
@en
Gary S Coombs
@es
Gary S Coombs
@nl
P1153
7004795926
P21
P31
P496
0000-0002-0711-185X