about
CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesisSelective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.Genomic instability in cancer.Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationThe SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.CRL4Cdt2: master coordinator of cell cycle progression and genome stabilityp21 in cancer: intricate networks and multiple activitiesCDK2-activating kinase (CAK): more questions than answers.Differential efficacy of 3-hydroxy-3-methylglutaryl CoA reductase inhibitors on the cell cycle of prostate cancer cells.Autocatalytic phosphorylation of CDK2 at the activating Thr160.DNA replication and genomic instability.Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
P50
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P50
name
Tarek Abbas
@ast
Tarek Abbas
@en
Tarek Abbas
@es
Tarek Abbas
@nl
type
label
Tarek Abbas
@ast
Tarek Abbas
@en
Tarek Abbas
@es
Tarek Abbas
@nl
prefLabel
Tarek Abbas
@ast
Tarek Abbas
@en
Tarek Abbas
@es
Tarek Abbas
@nl