CRL4Cdt2: master coordinator of cell cycle progression and genome stability
about
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypassSelective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cellsCullin family proteins and tumorigenesis: genetic association and molecular mechanismsPR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcriptionRegulation of Unperturbed DNA Replication by UbiquitylationEpigenetic events in liver cancer resulting from alcoholic liver diseaseRegulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome StabilityPDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δA novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionKSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTLInactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1Regulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.Thymine DNA glycosylase is a CRL4Cdt2 substrate.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometryNon-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseExpression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21(WAF1), Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cellsMitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos.MicroRNA transgene overexpression complements deficiency-based modifier screens in DrosophilaEmerging regulatory mechanisms in ubiquitin-dependent cell cycle control.The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.C/EBPα regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G1/S checkpoint.PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication StressExpression of an S phase-stabilized version of the CDK inhibitor Dacapo can alter endoreplication.Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligaseProteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylationAdenovirus E1A oncogene induces rereplication of cellular DNA and alters DNA replication dynamics.Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ.
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CRL4Cdt2: master coordinator of cell cycle progression and genome stability
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@ast
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@en
type
label
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@ast
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@en
prefLabel
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@ast
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@en
P2860
P356
P1433
P1476
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
@en
P2860
P304
P356
10.4161/CC.10.2.14530
P577
2011-01-15T00:00:00Z