about
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for RacP-Rex2, a new guanine-nucleotide exchange factor for RacPhosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damageStructural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and StaurosporineStructure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory MechanismRhoG regulates the neutrophil NADPH oxidaseSequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophilsRegulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survivalThe role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.Phosphoinositide 3-kinases as drug targets in cancer.BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate.Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach.ARAP3 is essential for formation of lamellipodia after growth factor stimulation.Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents.Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits.Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.Localizing the lipid products of PI3Kγ in neutrophils.Purification of ARAP3 and characterization of GAP activities.Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.PI3Kβ plays a critical role in neutrophil activation by immune complexes.ARAP3 is a PI3K- and rap-regulated GAP for RhoA
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description
researcher
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wetenschapper
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հետազոտող
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name
Len R Stephens
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Len R Stephens
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Len R Stephens
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Len R Stephens
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type
label
Len R Stephens
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Len R Stephens
@en
Len R Stephens
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Len R Stephens
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prefLabel
Len R Stephens
@ast
Len R Stephens
@en
Len R Stephens
@es
Len R Stephens
@nl
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P1153
7102747513
P31
P496
0000-0002-2771-3487