about
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonismAntisense targeting of perlecan blocks tumor growth and angiogenesis in vivoA central function for perlecan in skeletal muscle and cardiovascular developmentPerlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis.Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTENPerlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signalingPeroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chainsHeparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activityMast Cells Produce a Unique Chondroitin Sulfate EpitopeDiverse cell signaling events modulated by perlecan.Perlecan expression influences the keratin 15-positive cell population fate in the epidermis of aging skinPerlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.Oxidative damage to extracellular matrix and its role in human pathologies.The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling.Perlecan immunolocalizes to perichondrial vessels and canals in human fetal cartilaginous primordia in early vascular and matrix remodeling events associated with diarthrodial joint development.Matrix components and scaffolds for sustained islet function.Mechanisms and consequences of oxidative damage to extracellular matrix.Recombinant production of proteoglycans and their bioactive domains.Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.Transcriptional complexity of the HSPG2 gene in the human mast cell line, HMC-1.Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk.Expression of Biglycan in First Trimester Chorionic Villous Sampling Placental Samples and Altered Function in Telomerase-Immortalized Microvascular Endothelial Cells.The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation.Perspectives on the use of biomaterials to store platelets for transfusion.Altered decorin leads to disrupted endothelial cell function: a possible mechanism in the pathogenesis of fetal growth restriction?Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling.The localisation of inflammatory cells and expression of associated proteoglycans in response to implanted chitosan.Endocytosis of cerium oxide nanoparticles and modulation of reactive oxygen species in human ovarian and colon cancer cells.Bioengineered heparin: is there a future for this form of the successful therapeutic?Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.Syndecan-4 is associated with beta-cells in the pancreas and the MIN6 beta-cell line.Cellular uptake and reactive oxygen species modulation of cerium oxide nanoparticles in human monocyte cell line U937.Hyaluronan coated cerium oxide nanoparticles modulate CD44 and reactive oxygen species expression in human fibroblasts.Characterization and purification of glycosaminoglycans from crude biological samples.Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.Nitration of tyrosines in complement factor H domains alters its immunological activity and mediates a pathogenic role in age related macular degenerationPerlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.Isolation and purification of proteoglycans.
P50
Q24303934-0858BCD1-6450-40A1-8DF3-6161A2EE98BFQ24564477-B9AD501C-B0F2-47AD-A3D6-A0F3C64F7F70Q24648227-2C462CA8-0DD7-4086-9F79-EE8744214E2CQ24653433-0A877D18-8DD3-4406-B28A-6BDE98D3F70EQ27021503-900C718D-AD97-4D0C-928F-9526E5BFE81CQ28570341-151888AA-E7BA-4B3C-A417-6B2FDCEC0F12Q30452968-0EBE7DB9-D745-4E96-B856-71262A55C585Q33943403-8EF7BAB1-C1A1-4D02-97DB-4620288DC715Q33975294-8CAB31D7-BD01-4159-85B5-0E8A6D991B52Q36332766-3C90D4F9-E2FD-41EA-BD9D-0CB3FADEDB61Q36742597-D63B49B9-C001-47E5-BCCA-F2582EF736DEQ37020797-36E81D60-0FC9-45C3-BCCA-1DDFC7B105EFQ37049108-32B6460C-CF33-4FEC-9A3C-465666C72380Q37135613-9F1B2350-FD5A-4E5B-A646-2FF9E393670AQ37142535-C19173F3-78F3-4FFE-80B7-0CFE13A9C715Q37271260-0C2F0599-7949-451C-BC6A-53A6B92FFC66Q37643577-329B2D2B-E753-4586-BA25-AA7F627459A6Q37863116-982FC38B-8C4A-4997-B246-D53C2AA4D511Q37936512-32AEA46F-9591-484A-BC50-EFA39F7F0772Q38082553-28625B54-BDB6-447C-8CDA-A5274490C129Q38266373-2C2A4BCD-98F5-4BF2-BDEA-FD7CBBD70D39Q38310212-8F023032-30DD-43FA-B033-7CE493852010Q38616484-D7180B0B-3CD9-47E6-A737-9C99B37B1BC2Q38707762-8C696790-37A5-47DE-9F8A-DF3267F92622Q38710574-2477BC57-50F0-44AF-9398-8CF9BA498F35Q38846202-26B819F5-A4C2-4159-B713-8118C56DE684Q38982810-B0F7E2A5-1993-4B01-A91D-59D50F238142Q39005090-FE305EC7-F781-4242-B8B6-E1ECE0B99F41Q39061785-9EEA601D-2037-4866-A597-EDACA87B950DQ39112132-3A144E38-C7B0-470C-A4D3-9D6C486CEC15Q39180228-4322A3D9-950E-40ED-8282-015BC1E854A5Q39227219-E3926A98-9635-43A6-AA4F-3F0EE15FBCD0Q39300907-9AE05BAD-7E22-4BE8-BBDF-FDCD60511A3AQ39306955-E6CAE0C1-D736-4456-AFD1-42CA8189DB68Q39945487-91E7EC56-9642-4AB9-8A0C-2680FDD6C974Q40138290-765D58ED-A3DE-4030-92B3-F0EE38CA24E5Q40242609-5A7F60A9-66CB-4012-ACDF-8E7264DC52ECQ40345997-F62B1BDE-563F-40F8-B702-B5D99A015C98Q40380295-2001FEE3-528A-4320-B59A-48F2D3A915E6Q40724158-D3DBF11D-00CA-4A82-AFA9-1C54DC003D1C
P50
description
researcher
@en
name
J M Whitelock
@en
J M Whitelock
@nl
type
label
J M Whitelock
@en
J M Whitelock
@nl
prefLabel
J M Whitelock
@en
J M Whitelock
@nl
P106
P31
P496
0000-0003-1835-802X