%D8%A8%D9%8A%D8%AA%D8%A7_%D8%B3%D9%8A%D9%83%D8%B1%D9%8A%D8%AA%D8%A7%D8%B2_1BACE1Beta-SekretaseBeta-secretase_1Beta-secretasaBACE1%CE%92-%E3%82%BB%E3%82%AF%E3%83%AC%E3%82%BF%E3%83%BC%E3%82%BC1Beta-secretasis_1%D0%91%D0%B5%D1%82%D0%B0-%D1%81%D0%B5%D0%BA%D1%80%D0%B5%D1%82%D0%B0%D0%B7%D0%B0Memapsin_2Memapsin_2BACE1Q737488
about
sameAs
BACE1:GGA1;2;3NAT8;8B acetylate BACE1BACE1 translocates from ER lumen to Golgi apparatusFURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)Unknown deacetylase deacetylates 7K-BACE1(46-501)BACE1(46-501) translocates from Golgi lumen to plasma membraneBACE1 binds GGA1;2;3BACE1:GGA1;2;3 translocates from plasma membrane to endosomeBACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)
P527
P688
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACEThe transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrateIdentification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzymeThe disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblastsA novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor proteinInhibition of beta A4 production by specific modulation of beta-secretase activityBACE (beta-secretase) modulates the processing of APLP2 in vivoFlotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sortingHuman aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor proteinThe ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.BACE is degraded via the lysosomal pathway.GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.MiR-124 acts as a target for Alzheimer's disease by regulating BACE1.
P921
Q50269725-620E0818-4640-4D9C-91EF-5F8A07466A9EQ50296934-6E50AB90-0DF1-448C-AC7F-1D4DDE8A3775Q50296935-B064DF4C-946C-4833-AAFE-A9D2F3F9EF9CQ50296935-CA224314-9305-4517-AF99-EB9949226F6DQ50296936-FCC21D0B-85CE-4F34-9F97-49C855331AADQ50296938-B7635A4C-E3A5-49B7-84B1-19F1476E4D9BQ50296939-97B3F036-99A4-4D04-AE01-4D3228D907A6Q50296939-D02AC6F8-F543-47D2-817A-628A588E5669Q50296940-B93B0FD5-405E-4C4A-BCD9-47E5CB7483E7Q50296941-12454BE8-4E64-4197-A514-27C7014CA791Q50296943-7E766662-53FD-4155-9B73-7B566A57C589
P527
Q22010705-AE0905EF-714C-441F-9F64-94AF23EB8437Q24291471-C687EA07-10A7-4ECA-B795-136F6409E3E1Q24294704-517D7023-FA02-4479-8A77-98A40376CDCEQ24300851-594DDC7D-09BA-410C-A9CD-249279B472A6Q24307875-1929803F-5CE0-450D-B6D9-A433F95617DAQ24312803-94953ED2-79BC-4D2A-A47D-EA0F328555EDQ24317112-09F5189E-6489-4A36-B8D8-A40E93AD23D2Q24336570-4B6DFD59-6245-430D-9FEA-CED05F8FFE3BQ24338925-C44DD8E2-48DF-44BF-9E19-A8BBCCB5EC10Q24650599-289E3EC4-1F35-4324-9C75-C781580FF38AQ35187927-6EF8A5CA-D89F-494B-8A55-64834EF95A89Q36466753-856F973D-E90F-4369-9FEB-FAD0E83151E2Q37117319-62C52672-1B9E-46EC-AA0E-4BBDE0C9FB04Q37362443-343B352A-16A7-42DF-9BCD-6BE1B6ACF365Q38777715-B2971187-398E-4A23-8802-C78E8AA362CCQ40395411-B0EF6E58-B064-442B-AB73-AB56A82653A5Q40424279-C8649103-63E1-46A9-8605-00EC6CDB7207Q49418229-6036721F-1C6B-4A2D-8735-02FE45D2915F
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Beta-secretase 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
酵素
@ja
name
BACE1
@cy
BACE1
@fr
BACE1
@uk
Beta-Sekretase
@de
Beta-secretasa
@es
Beta-secretase 1
@en
Beta-secretasis 1
@la
Memapsin 2
@sh
Memapsin 2
@sr
Β-セクレターゼ1
@ja
type
label
BACE1
@cy
BACE1
@fr
BACE1
@uk
Beta-Sekretase
@de
Beta-secretasa
@es
Beta-secretase 1
@en
Beta-secretasis 1
@la
Memapsin 2
@sh
Memapsin 2
@sr
Β-セクレターゼ1
@ja
altLabel
APP beta-secretase
@en
ASP2
@en
BACE1
@en
Beta-site amyloid precursor protein cleaving enzyme 1
@en
asp 2
@en
aspartyl protease 2
@en
beta-secretase 1 precursor variant 1
@en
beta-secretase 1
@en
beta-site APP cleaving enzyme 1
@en
beta-site APP-cleaving enzyme
@en
prefLabel
BACE1
@cy
BACE1
@fr
BACE1
@uk
Beta-Sekretase
@de
Beta-secretasa
@es
Beta-secretase 1
@en
Beta-secretasis 1
@la
Memapsin 2
@sh
Memapsin 2
@sr
Β-セクレターゼ1
@ja
P361
P527
P637
P638
P680
P681
P682
P705
P352
P6366
P646
P2888
P31
P352
P591
P6366
2777749304
2910719675
P637
NP_001193977
NP_001193978
P638
P646
P680
P681
P682
P702
P703
P705
ENSP00000318585
ENSP00000402228
ENSP00000403685
ENSP00000422461
ENSP00000424536
ENSP00000431848
ENSP00000434486
ENSP00000475171
ENSP00000475405
P7260
8.A.32.1.1