Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein - Test2 - elhamkhani - TriplyDB

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

http://www.wikidata.org/entity/Q24650599

about

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients Signaling effect of amyloid-beta(42) on the processing of AbetaPP Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging TDP-43: a new player on the AD field?The role of APP and BACE1 trafficking in APP processing and amyloid-β generation Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease Toward the structure of presenilin/γ-secretase and presenilin homologs Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -Secretase Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein Production A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations Camel and bovine chymosin: the relationship between their structures and cheese-making properties Rab GTPases, membrane trafficking and diseases Proteomic Substrate Identification for Membrane Proteases in the Brain Post-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the protein Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's disease Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein Proteolytic processing of Alzheimer's β-amyloid precursor protein BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease Trafficking and proteolytic processing of APP Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease BACE1 expression and activity: relevance in Alzheimer's disease Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation Conformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation Equilibria The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.Tailoring of membrane proteins by alternative splicing of pre-mRNA.BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

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P2860

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

http://www.wikidata.org/entity/Q24650599

description

2000 nî lūn-bûn

@nan

2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Human aspartic protease memaps ...... beta-amyloid precursor protein

@ast

Human aspartic protease memaps ...... beta-amyloid precursor protein

@en

Human aspartic protease memaps ...... beta-amyloid precursor protein

@nl

type

label

Human aspartic protease memaps ...... beta-amyloid precursor protein

@ast

Human aspartic protease memaps ...... beta-amyloid precursor protein

@en

Human aspartic protease memaps ...... beta-amyloid precursor protein

@nl

prefLabel

Human aspartic protease memaps ...... beta-amyloid precursor protein

@ast

Human aspartic protease memaps ...... beta-amyloid precursor protein

@en

Human aspartic protease memaps ...... beta-amyloid precursor protein

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Proceedings of the National Academy of Sciences of the United States of America

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Human aspartic protease memaps ...... beta-amyloid precursor protein

@en

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A Dashti

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D Downs

http://www.w3.org/2001/XMLSchema#string

G Koelsch

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S Wu

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X Lin

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

Evolution in the structure and function of aspartic proteases

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

Translating cell biology into therapeutic advances in Alzheimer's disease.

Cellular mechanisms of beta-amyloid production and secretion

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.

Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases.

Generation of amyloid beta protein from its precursor is sequence specific.

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases.

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1456-60

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scholarly article

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88931

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10.1073/PNAS.97.4.1456

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P433

4

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P478

97

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2000-02-15T00:00:00Z

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10677483

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amyloid-beta metabolic process

Beta-secretase 1

P932

26455

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