Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
about
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease miceThe Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinGGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β productionAmyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patientsSignaling effect of amyloid-beta(42) on the processing of AbetaPPPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHStepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsAmyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET ImagingTDP-43: a new player on the AD field?The role of APP and BACE1 trafficking in APP processing and amyloid-β generationInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseToward the structure of presenilin/γ-secretase and presenilin homologsComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretasePotent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluationCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionA therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivoDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseFlexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsCamel and bovine chymosin: the relationship between their structures and cheese-making propertiesRab GTPases, membrane trafficking and diseasesProteomic Substrate Identification for Membrane Proteases in the BrainPost-translational modification of bone morphogenetic protein-1 is required for secretion and stability of the proteinBrain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticThe cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activityβ-secretase inhibitor; a promising novel therapeutic drug in Alzheimer's diseaseGenetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor proteinProteolytic processing of Alzheimer's β-amyloid precursor proteinBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseaseTrafficking and proteolytic processing of APPCysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's diseaseBACE1 expression and activity: relevance in Alzheimer's diseaseMultiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generationConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.Tailoring of membrane proteins by alternative splicing of pre-mRNA.BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
P2860
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P2860
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Human aspartic protease memaps ...... beta-amyloid precursor protein
@ast
Human aspartic protease memaps ...... beta-amyloid precursor protein
@en
Human aspartic protease memaps ...... beta-amyloid precursor protein
@nl
type
label
Human aspartic protease memaps ...... beta-amyloid precursor protein
@ast
Human aspartic protease memaps ...... beta-amyloid precursor protein
@en
Human aspartic protease memaps ...... beta-amyloid precursor protein
@nl
prefLabel
Human aspartic protease memaps ...... beta-amyloid precursor protein
@ast
Human aspartic protease memaps ...... beta-amyloid precursor protein
@en
Human aspartic protease memaps ...... beta-amyloid precursor protein
@nl
P2093
P2860
P3181
P356
P1476
Human aspartic protease memaps ...... beta-amyloid precursor protein
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.97.4.1456
P407
P577
2000-02-15T00:00:00Z