Oncogenic protein interfaces: small molecules, big challenges.
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Drugging the undruggables: exploring the ubiquitin system for drug developmentSurfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsApplication of fragment-based screening to the design of inhibitors of Escherichia coli DsbAProperty Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Structure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine-G-Protein-Coupled-Receptor InterfaceFAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistanceCurrent and future targeted therapies for non-small-cell lung cancers with aberrant EGF receptorsUnlocking the secrets to protein-protein interface drug targets using structural mass spectrometry techniquesStructure-based inhibition of protein-protein interactions.Targeting kinase signaling pathways with constrained peptide scaffolds.PPIMpred: a web server for high-throughput screening of small molecules targeting protein-protein interaction.Identification of small molecule inhibitors of the Aurora-A/TPX2 complexProtein painting reveals solvent-excluded drug targets hidden within native protein-protein interfaces.Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and interventionIn vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.The SIX1-EYA transcriptional complex as a therapeutic target in cancer.Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.A unified lead-oriented synthesis of over fifty molecular scaffolds.Identification of protein-ligand binding sites by the level-set variational implicit-solvent approachGranulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.Alternative modulation of protein-protein interactions by small moleculesTargeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?DARC 2.0: Improved Docking and Virtual Screening at Protein Interaction SitesState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Combined Use of Oligopeptides, Fragment Libraries, and Natural Compounds: A Comprehensive Approach To Sample the Druggability of Vascular Endothelial Growth Factor.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1Virtual Screening and Experimental Validation Identify Novel Inhibitors of the Plasmodium falciparum Atg8-Atg3 Protein-Protein Interaction.Pooled screening for antiproliferative inhibitors of protein-protein interactions.AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.Structure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivoScreening-based approaches to identify small molecules that inhibit protein-protein interactions.Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.Modular, One-Pot, Sequential Aziridine Ring Opening-S(N)Ar Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams.Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: The Hemoglobin Case.Application of isothermal titration calorimetry as a tool to study natural product interactions.Modulating protein-protein interactions: the potential of peptides.Targeting the canonical Wnt/β-catenin pathway in hematological malignancies.Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.
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Oncogenic protein interfaces: small molecules, big challenges.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Oncogenic protein interfaces: small molecules, big challenges.
@en
type
label
Oncogenic protein interfaces: small molecules, big challenges.
@en
prefLabel
Oncogenic protein interfaces: small molecules, big challenges.
@en
P2860
P50
P356
P1476
Oncogenic protein interfaces: small molecules, big challenges
@en
P2093
Jessica K Holien
Tracy L Nero
P2860
P2888
P304
P356
10.1038/NRC3690
P407
P577
2014-03-13T00:00:00Z
P6179
1016185901