The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
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Function, regulation and pathological roles of the Gab/DOS docking proteinsUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsCritical role for Kalirin in nerve growth factor signaling through TrkA.PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafishA novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationEssential role of Gab1 for signaling by the c-Met receptor in vivoThe docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathwayMET: a critical player in tumorigenesis and therapeutic targetSustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesisMet receptor tyrosine kinase: enhanced signaling through adapter proteinsGC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesRole of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo)Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factorGab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signalingPak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptorSrc-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptorCoupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responsesERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinaseNew role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayA novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signalingGab1 is an integrator of cell death versus cell survival signals in oxidative stressMet receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodiaHost adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation.Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis.The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysDistinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase.Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseThe multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair
P2860
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P2860
The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@ast
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@en
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@nl
type
label
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@ast
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@en
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@nl
prefLabel
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@ast
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@en
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@nl
P2093
P2860
P3181
P356
P1476
The Gab1 PH domain is required ...... e met receptor tyrosine kinase
@en
P2093
C R Maroun
M A Naujokas
M Holgado-Madruga
T M Fournier
P2860
P304
P3181
P356
10.1128/MCB.19.3.1784
P407
P577
1999-03-01T00:00:00Z