Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection
about
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulinBinary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteinsAnthrax lethal and edema toxins in anthrax pathogenesisBacillus anthracis edema factor substrate specificity: evidence for new modes of actionThe potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shockLethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapyDifferential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virusNoninvasive imaging technologies reveal edema toxin as a key virulence factor in anthraxMolecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.Peptide inhibitors MAP the way towards fighting anthrax pathogenesis.Cationic polyamines inhibit anthrax lethal factor proteaseNovel inhibitors of anthrax edema factor.Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.Structural basis of anthrax edema factor neutralization by a neutralizing antibodyAntiviral treatment of chronic hepatitis B virus (HBV) infectionsAcyclic nucleoside phosphonates: a key class of antiviral drugs.A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.B. anthracis associated cardiovascular dysfunction and shock: the potential contribution of both non-toxin and toxin componentsDesigning inhibitors of anthrax toxinBacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in miceEmergence of anthrax edema toxin as a master manipulator of macrophage and B cell functionsEffects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema FactorInhibitors of membranous adenylyl cyclases.Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.Antivirals and antiviral strategies.Antitoxins: novel strategies to target agents of bioterrorism.The evolving field of biodefence: therapeutic developments and diagnostics.Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signalingAntiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillusNew insights into the pathogenesis and treatment of anthrax toxin-induced shock.Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism.B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activityThe adenylyl cyclase activity of anthrax edema factor.Fusion protein of Delta 27LFn and EFn has the potential as a novel anthrax toxin inhibitor.An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.
P2860
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P2860
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Selective inhibition of anthra ...... ic hepatitis B virus infection
@ast
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en-gb
Selective inhibition of anthra ...... ic hepatitis B virus infection
@nl
type
label
Selective inhibition of anthra ...... ic hepatitis B virus infection
@ast
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en-gb
Selective inhibition of anthra ...... ic hepatitis B virus infection
@nl
prefLabel
Selective inhibition of anthra ...... ic hepatitis B virus infection
@ast
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en-gb
Selective inhibition of anthra ...... ic hepatitis B virus infection
@nl
P2093
P2860
P356
P1476
Selective inhibition of anthra ...... ic hepatitis B virus infection
@en
P2093
Chyung-Ru Wang
Craig S Gibbs
Michael I Zimmer
Natalia L Zhukovskaya
Pamela Bergson
Sandriyana Soelaiman
Yuequan Shen
P2860
P304
P356
10.1073/PNAS.0306552101
P407
P50
P577
2004-03-02T00:00:00Z