Antitoxins: novel strategies to target agents of bioterrorism.
about
Gram-positive and gram-negative bacterial toxins in sepsis: a brief reviewObstructing toxin pathways by targeted pore blockageChemical inhibitors of the type three secretion system: disarming bacterial pathogensLethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapyAntitoxin Treatment of Inhalation Anthrax: A Systematic ReviewSuppressive effects of anthrax lethal toxin on megakaryopoiesisDelayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatmentPost-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model.Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities.Characterization of a novel high-affinity monoclonal immunoglobulin G antibody against the ricin B subunit.Polyvalent inhibitors of anthrax toxin that target host receptorsIdentification of small-molecule inhibitors of ricin and shiga toxin using a cell-based high-throughput screenAn anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design.Prolonged prophylactic protection from botulism with a single adenovirus treatment promoting serum expression of a VHH-based antitoxin protein.A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.Direct inhibition of T-lymphocyte activation by anthrax toxins in vivo.Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc regionA chimeric protein that functions as both an anthrax dual-target antitoxin and a trivalent vaccine.BiP negatively affects ricin transport.Erythrocytic mobilization enhanced by the granulocyte colony-stimulating factor is associated with reduced anthrax-lethal-toxin-induced mortality in mice.Genetic characterization and comparison of Clostridium botulinum isolates from botulism cases in Japan between 2006 and 2011.Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxicationProtective effects of anti-ricin A-chain antibodies delivered intracellularly against ricin-induced cytotoxicity.Erythropoiesis suppression is associated with anthrax lethal toxin-mediated pathogenic progressionDesigning inhibitors of anthrax toxinTargeting MgrA-mediated virulence regulation in Staphylococcus aureusPreparation of abiotic polymer nanoparticles for sequestration and neutralization of a target peptide toxin.Inhibition of anthrax protective antigen outside and inside the cell.Amiodarone and bepridil inhibit anthrax toxin entry into host cellsEngineered nanoparticles mimicking cell membranes for toxin neutralization.Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating groupDNA vaccines targeting heavy chain C-terminal fragments of Clostridium botulinum neurotoxin serotypes A, B, and E induce potent humoral and cellular immunity and provide protection from lethal toxin challengeA relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.Past, imminent and future human medical countermeasures for anthrax.A neutralizing antibody to the a chain of abrin inhibits abrin toxicity both in vitro and in vivo.New insights into the pathogenesis and treatment of anthrax toxin-induced shock.Inactivation of rho GTPases by statins attenuates anthrax lethal toxin activity.Efficient neutralization of antibody-resistant forms of anthrax toxin by a soluble receptor decoy inhibitor
P2860
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P2860
Antitoxins: novel strategies to target agents of bioterrorism.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Antitoxins: novel strategies to target agents of bioterrorism.
@ast
Antitoxins: novel strategies to target agents of bioterrorism.
@en
type
label
Antitoxins: novel strategies to target agents of bioterrorism.
@ast
Antitoxins: novel strategies to target agents of bioterrorism.
@en
prefLabel
Antitoxins: novel strategies to target agents of bioterrorism.
@ast
Antitoxins: novel strategies to target agents of bioterrorism.
@en
P2860
P356
P1476
Antitoxins: novel strategies to target agents of bioterrorism.
@en
P2093
G Jonah A Rainey
John A T Young
P2860
P2888
P304
P356
10.1038/NRMICRO977
P407
P577
2004-09-01T00:00:00Z