Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development
about
Parathyroid hormone is essential for normal fetal bone formationReduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMPCartilage to bone transitions in health and diseaseThe role of peptides in bone healing and regeneration: a systematic reviewThe COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1BSoluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survivalCystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathwayPartial characterization of cell-type X collagen interactions.Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management.Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormoneAblation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development.Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylation.Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.Enchondromatosis: insights on the different subtypes.The parathyroid hormone, its fragments and analogues--potent bone-builders for treating osteoporosis.Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes.Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal lifeChondrocyte-matrix attachment complexes mediate survival and differentiation.PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes.Enchondromatosis (Ollier disease, Maffucci syndrome) is not caused by the PTHR1 mutation p.R150C.The fate of the terminally differentiated chondrocyte: evidence for microenvironmental regulation of chondrocyte apoptosis.Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasiaA Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development.FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathwayChondrocyte apoptosis is not essential for cartilage calcification: evidence from an in vitro avian model.Dual pathways to endochondral osteoblasts: a novel chondrocyte-derived osteoprogenitor cell identified in hypertrophic cartilageProfiling microRNA expression during fracture healing.Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation.Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundantThe tissue dependent interactions between p53 and Bcl-2 in vivo.Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation.Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repairNuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cellsPivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.Molecular basis for skeletal variation: insights from developmental genetic studies in mice.Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma.Role of Bcl2 in osteoclastogenesis and PTH anabolic actions in bone
P2860
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P2860
Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Bcl-2 lies downstream of parat ...... on during skeletal development
@ast
Bcl-2 lies downstream of parat ...... on during skeletal development
@en
Bcl-2 lies downstream of parat ...... on during skeletal development
@en-gb
Bcl-2 lies downstream of parat ...... on during skeletal development
@nl
type
label
Bcl-2 lies downstream of parat ...... on during skeletal development
@ast
Bcl-2 lies downstream of parat ...... on during skeletal development
@en
Bcl-2 lies downstream of parat ...... on during skeletal development
@en-gb
Bcl-2 lies downstream of parat ...... on during skeletal development
@nl
prefLabel
Bcl-2 lies downstream of parat ...... on during skeletal development
@ast
Bcl-2 lies downstream of parat ...... on during skeletal development
@en
Bcl-2 lies downstream of parat ...... on during skeletal development
@en-gb
Bcl-2 lies downstream of parat ...... on during skeletal development
@nl
P2093
P2860
P921
P3181
P356
P1476
Bcl-2 lies downstream of parat ...... on during skeletal development
@en
P2093
A E Broadus
W M Philbrick
P2860
P304
P3181
P356
10.1083/JCB.136.1.205
P407
P577
1997-01-13T00:00:00Z