Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling - Wikidata - thesis-toulmin - TriplyDB

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

http://www.wikidata.org/entity/Q24536092

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PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3 Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Signaling by target of rapamycin proteins in cell growth control PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex Amino acids as regulators of gene expression Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase Updates of mTOR inhibitors Spatial regulation of the mTORC1 system in amino acids sensing pathway Emerging pharmacotherapies for neurodevelopmental disorders Rapamycin and mTOR kinase inhibitors The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation Recent advances in understanding leptin signaling and leptin resistance Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis Behavioral phenotypes of genetic mouse models of autism.Oncogenes strike a balance between cellular growth and homeostasis Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends Leucine and mTORC1: a complex relationship Regulation of mTORC1 by PI3K signaling Phosphoinositides: tiny lipids with giant impact on cell regulation Nutrient-sensing mechanisms across evolution Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex Response and acquired resistance to everolimus in anaplastic thyroid cancer mTOR and MAPK: from localized translation control to epilepsy Left-right asymmetry in the light of TOR: An update on what we know so far Discovery of Rare Mutations in Autism: Elucidating Neurodevelopmental Mechanisms The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade mTOR signaling in tumorigenesis Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin Excessive Leucine-mTORC1-Signalling of Cow Milk-Based Infant Formula: The Missing Link to Understand Early Childhood Obesity Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

http://www.wikidata.org/entity/Q24536092

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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Proceedings of the National Academy of Sciences of the United States of America

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Tuberous sclerosis complex-1 a ...... -mediated downstream signaling

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P2093

Andrew R Tee

http://www.w3.org/2001/XMLSchema#string

Brendan D Manning

http://www.w3.org/2001/XMLSchema#string

David J Kwiatkowski

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Diane C Fingar

http://www.w3.org/2001/XMLSchema#string

John Blenis

http://www.w3.org/2001/XMLSchema#string

Lewis C Cantley

http://www.w3.org/2001/XMLSchema#string

P2860

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

The TSC1 gene product, hamartin, negatively regulates cell proliferation

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

TOR, a central controller of cell growth.

Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

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13571-6

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scholarly article

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1664206

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10.1073/PNAS.202476899

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21

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99

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2002-10-15T00:00:00Z

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11139755

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12271141

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129715

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