A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
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Rapamycin and its analogues (rapalogs) for tuberous sclerosis complexTBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translationIdentification and characterization of the interaction between tuberin and 14-3-3zetaThe TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeletonRibosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3)Regulation of TSC2 by 14-3-3 bindingSignaling by target of rapamycin proteins in cell growth controlRegulation of mTOR and cell growth in response to energy stress by REDD1.Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityTumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseMammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthEfficacy and safety of sirolimus in lymphangioleiomyomatosis.Spatial regulation of the mTORC1 system in amino acids sensing pathwayThe tuberous sclerosis complexThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthReversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosisA complex interplay between Akt, TSC2 and the two mTOR complexesTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisLife with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlRole of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathwaysRapamycin and rapalogs for tuberous sclerosis complexThe cilia-regulated proteasome and its role in the development of ciliopathies and cancerRapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta-analysisRegulation of mTORC1 by PI3K signalingRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complexA genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylationCell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin BPam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complexAkt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysCoordinated regulation of protein synthesis and degradation by mTORC1PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascademTOR signaling in tumorigenesisRegulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
P2860
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P2860
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@ast
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@en
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@nl
type
label
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@ast
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@en
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@nl
prefLabel
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@ast
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@en
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@nl
P2093
P3181
P356
P1476
A mouse model of TSC1 reveals ...... se activity in Tsc1 null cells
@en
P2093
David J Kwiatkowski
Hiroaki Onda
Hongbing Zhang
Jennifer L Bandura
Kristina M Heiberger
Michael Glogauer
Nisreen el-Hashemite
P304
P3181
P356
10.1093/HMG/11.5.525
P407
P577
2002-03-01T00:00:00Z