The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity
about
The tyrosine kinase Syk regulates TPL2 activation signalsTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerRegulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinaseGenome remodelling in a basal-like breast cancer metastasis and xenograftCot/tpl2 participates in the activation of macrophages by adiponectin.IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinasesPhosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophagesPhosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.IκB kinase regulation of the TPL-2/ERK MAPK pathway.Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors.Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity.Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.Mechanism of direct degradation of IkappaBalpha by 20S proteasome.Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.
P2860
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P2860
The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activity
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The COOH-terminal domain of wi ...... y and kinase specific activity
@ast
The COOH-terminal domain of wi ...... y and kinase specific activity
@en
The COOH-terminal domain of wi ...... y and kinase specific activity
@nl
type
label
The COOH-terminal domain of wi ...... y and kinase specific activity
@ast
The COOH-terminal domain of wi ...... y and kinase specific activity
@en
The COOH-terminal domain of wi ...... y and kinase specific activity
@nl
prefLabel
The COOH-terminal domain of wi ...... y and kinase specific activity
@ast
The COOH-terminal domain of wi ...... y and kinase specific activity
@en
The COOH-terminal domain of wi ...... y and kinase specific activity
@nl
P2093
P2860
P1476
The COOH-terminal domain of wi ...... y and kinase specific activity
@en
P2093
José G Castaño
Maria Luisa Gándara
Pilar López
Raquel Hernando
P2860
P304
P356
10.1128/MCB.23.20.7377-7390.2003
P407
P577
2003-10-01T00:00:00Z