TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
about
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentProteostatic control of telomerase function through TRiC-mediated folding of TCAB1A quantitative telomeric chromatin isolation protocol identifies different telomeric statesHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationPinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localizationThe genetics of dyskeratosis congenitaFinding the end: recruitment of telomerase to telomeresProcessive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditionsIt all comes together at the ends: telomerase structure, function, and biogenesisMultiple facets of TPP1 in telomere maintenanceRPA facilitates telomerase activity at chromosome ends in budding and fission yeastsATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresThe shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulationThe TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivityGenomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactionsMultiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.Inhibition of telomerase recruitment and cancer cell deathIdentification of human TERT elements necessary for telomerase recruitment to telomeres.Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.Human telomerase: biogenesis, trafficking, recruitment, and activation.A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.Telomere protection by TPP1/POT1 requires tethering to TIN2SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin.Human telomeric proteins occupy selective interstitial sites.POT1-TPP1 regulates telomeric overhang structural dynamics.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.A Cajal body-independent pathway for telomerase trafficking in mice.The role of telomeres and telomerase in cancer research.Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1.Human CST promotes telomere duplex replication and general replication restart after fork stalling.Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic controlLoss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.Telomere maintenance mechanisms in cancer: clinical implicationsInherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling.Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA.Functional characterization of the TERRA transcriptome at damaged telomeres.Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase.
P2860
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P2860
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@ast
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@en
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@nl
type
label
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@ast
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@en
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@nl
prefLabel
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@ast
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@en
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@nl
P2093
P2860
P921
P3181
P356
P1476
TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo
@en
P2093
Eladio Abreu
Elena Aritonovska
Joachim Lingner
Michael P Terns
Patrick Reichenbach
Rebecca M Terns
P2860
P304
P3181
P356
10.1128/MCB.00240-10
P407
P577
2010-06-01T00:00:00Z