Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
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Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2βProtein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosisK+ channels as targets for specific immunomodulationThe intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humansEndothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MSCalcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observedLinking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric DisordersIon channels and transporters in lymphocyte function and immunityIdentification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channelsUnstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationDelineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferationPotassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal diseaseTargeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseasesGeneral Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMACClotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysisTRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activityNovel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3Molecular identification of Ca2+-activated K+ channels in parotid acinar cellsThe vascular effects of sodium tanshinone IIA sulphonate in rodent and human pregnancyCa2+-activated IK1 channels associate with lipid rafts upon cell swelling and mediate volume recoveryActive K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colonDefinitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factorCharacteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell lineAntibacterial activity of the venom of Heterometrus xanthopusRapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory DrugsRegulation of cellular communication by signaling microdomains in the blood vessel wall.Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.Interactions between NO, CO and an endothelium-derived hyperpolarizing factor (EDHF) in maintaining patency of the ductus arteriosus in the mouse.TRPV channels and vascular functionThe Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes.Novel role of endothelial BKCa channels in altered vasoreactivity following hypoxiaSequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.Arterial response to shear stress critically depends on endothelial TRPV4 expression.Inhibition of the K+ channel K(Ca)3.1 reduces TGF-β1-induced premature senescence, myofibroblast phenotype transition and proliferation of mesangial cells.Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureMolecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.
P2860
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P2860
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
description
2000 nî lūn-bûn
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2000 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2000 թվականի հուլիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Design of a potent and selecti ...... a potential immunosuppressant
@ast
Design of a potent and selecti ...... a potential immunosuppressant
@en
Design of a potent and selecti ...... a potential immunosuppressant
@nl
type
label
Design of a potent and selecti ...... a potential immunosuppressant
@ast
Design of a potent and selecti ...... a potential immunosuppressant
@en
Design of a potent and selecti ...... a potential immunosuppressant
@nl
prefLabel
Design of a potent and selecti ...... a potential immunosuppressant
@ast
Design of a potent and selecti ...... a potential immunosuppressant
@en
Design of a potent and selecti ...... a potential immunosuppressant
@nl
P2093
P2860
P3181
P356
P1476
Design of a potent and selecti ...... a potential immunosuppressant
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.97.14.8151
P407
P577
2000-07-05T00:00:00Z