Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands
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Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2‘ Ligands in Pseudosymmetric Dipeptide IsosteresHIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant VariantsEvaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug ResistanceStructure-Based Design, Synthesis, and Structure−Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating PhenyloxazolidinonesSubstrate Envelope-Designed Potent HIV-1 Protease Inhibitors to Avoid Drug ResistanceDesign, Synthesis, and Biological and Structural Evaluations of Novel HIV-1 Protease Inhibitors To Combat Drug ResistanceFINDSITE: a threading-based approach to ligand homology modelingA molecular mechanics approach to modeling protein-ligand interactions: relative binding affinities in congeneric series.Molecular Basis for Drug Resistance in HIV-1 ProteaseA summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.Modeling Protein-Ligand Binding by Mining Minima.Interdependence of Inhibitor Recognition in HIV-1 Protease.Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition.New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitorsAdditivity in the analysis and design of HIV protease inhibitors.Testing the substrate-envelope hypothesis with designed pairs of compounds.Tetrahydrofuran, tetrahydropyran, triazoles and related heterocyclic derivatives as HIV protease inhibitors.Second generation HIV protease inhibitors against resistant virus.Recent patents and emerging therapeutics for HIV infections: a focus on protease inhibitors.Scoring and lessons learned with the CSAR benchmark using an improved iterative knowledge-based scoring function.Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins.Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.Synthesis, characterization, and antibacterial activities of novel sulfonamides derived through condensation of amino group containing drugs, amino acids, and their analogs.The challenge of developing robust drugs to overcome resistance.Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides.Hydroxyethylamine derivatives as HIV-1 protease inhibitors: a predictive QSAR modelling study based on Monte Carlo optimization.Reaction mechanisms of carbon dioxide, ethylene oxide and amines catalyzed by ionic liquids BmimBr and BmimOAc: a DFT study.Fast and accurate determination of the relative binding affinities of small compounds to HIV-1 protease using non-equilibrium work.Synthesis, characterization and in vivo evaluation of [(62)Zn]-benzo-δ-sultam complex as a possible pet imaging agent.A straightforward one-pot synthesis of bioactive N-aryl oxazolidin-2-ones via a highly efficient Fe3O4@SiO2-supported acetate-based butylimidazolium ionic liquid nanocatalyst under metal- and solvent-free conditions
P2860
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P2860
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@ast
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@en
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@nl
type
label
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@ast
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@en
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@nl
prefLabel
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@ast
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@en
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@nl
P2093
P356
P1476
Discovery of HIV-1 protease in ...... rboxamides as novel P2 ligands
@en
P2093
Celia A Schiffer
G S Kiran Kumar Reddy
Madhavi N L Nalam
Saima Ghafoor Anjum
Tariq M Rana
P304
P356
10.1021/JM060666P
P407
P577
2006-12-14T00:00:00Z