Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
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Phosphorylation-dependent activity of the deubiquitinase DUBAStructural basis of Wnt recognition by FrizzledModulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?The osteocyte as a therapeutic target in the treatment of osteoporosisFrizzled homolog proteins, microRNAs and Wnt signaling in cancerThe DAN family: modulators of TGF-β signaling and beyondCrystal structures of the extracellular domain of LRP6 and its complex with DKK1Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt SignalingStructural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6Structural Studies of Wnts and Identification of an LRP6 Binding SiteWNT signaling in bone homeostasis and disease: from human mutations to treatmentsAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibitionDimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chainsWnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodiesIntrinsic disorder in spondins and some of their interacting partners.A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.Engineering potent long-acting variants of the Wnt inhibitor DKK2Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity.Updating the Wnt pathways.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.Identification of a novel inhibitor of the canonical Wnt pathway.Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.Dual-color dual-focus line-scanning FCS for quantitative analysis of receptor-ligand interactions in living specimensDesignation of a novel DKK1 multiepitope DNA vaccine and inhibition of bone loss in collagen-induced arthritic mice.Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip developmentWnt signaling in mammary glands: plastic cell fates and combinatorial signaling.Frizzled and LRP5/6 receptors for Wnt/β-catenin signalingWnt/β-catenin signaling plays a key role in the development of spondyloarthritis.A flow sensing model for mesenchymal stromal cells using morphogen dynamics.A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.The polycystin complex mediates Wnt/Ca(2+) signalling.A novel baculovirus vector for the production of nonfucosylated recombinant glycoproteins in insect cellsDrug discovery approaches to target Wnt signaling in cancer stem cells.Identifying and characterizing promiscuous targets: implications for virtual screening.
P2860
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P248
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P2860
Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
description
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2010
@ast
im März 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/03/19)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/03/19)
@nl
наукова стаття, опублікована в березні 2010
@uk
name
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@ast
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@en
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@nl
type
label
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@ast
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@en
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@nl
prefLabel
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@ast
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@en
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@nl
P2093
P2860
P921
P3181
P356
P1476
Reconstitution of a frizzled8. ...... and Dkk1 binding sites on LRP6
@en
P2093
Christine Tam
Eric Bourhis
J. Fernando Bazan
James Ernst
Jiyoung Hwang
Mike Costa
Rami N. Hannoush
Yvonne Franke
P2860
P304
P3181
P356
10.1074/JBC.M109.092130
P407
P577
2010-03-19T00:00:00Z