Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. - Wikidata - thesis-toulmin - TriplyDB

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

http://www.wikidata.org/entity/Q33659925

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Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer Synaptic Wnt/GSK3β Signaling Hub in Autism Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?The osteocyte as a therapeutic target in the treatment of osteoporosis Frizzled homolog proteins, microRNAs and Wnt signaling in cancer Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling Wnt signaling in bone and muscle LRP5 and LRP6 in development and disease Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition Both canonical and non-canonical Wnt signaling independently promote stem cell growth in mammospheres WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer.Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy.Genetic methylation and lymphoid malignancies: biomarkers of tumor progression and targeted therapy.Salinomycin suppresses LRP6 expression and inhibits both Wnt/β-catenin and mTORC1 signaling in breast and prostate cancer cells Oral epithelial stem cells - implications in normal development and cancer metastasis.Remodeling of endogenous mammary epithelium by breast cancer stem cells Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity.Updating the Wnt pathways.Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization.Receptor heterodimerization as a novel mechanism for the regulation of Wnt/β-catenin signaling.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.Triple-negative breast cancer: new perspectives for targeted therapies.Planar cell polarity aligns osteoblast division in response to substrate strain Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.A new tumour suppressor enters the network of intestinal progenitor cell homeostasis.Sclerostin inhibits osteoblast differentiation without affecting BMP2/SMAD1/5 or Wnt3a/β-catenin signaling but through activation of platelet-derived growth factor receptor signaling in vitro Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila.Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer.Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling Wnt/β-catenin signaling plays a key role in the development of spondyloarthritis.Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial Cells Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.

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P2860

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

http://www.wikidata.org/entity/Q33659925

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibition of tumorigenesis dr ...... ng regions by LRP6 antibodies.

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P2093

Alwin G Schuller

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Beatriz Ospina

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Darrin D Stuart

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David Stover

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Feng Cong

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Holger Heine

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Ingo M Klagge

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Jeffery A Porter

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Jing Yuan

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John Green

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P2860

LDL-receptor-related proteins in Wnt signal transduction

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Wnt/beta-catenin signaling: components, mechanisms, and diseases

Structure of the LDL receptor extracellular domain at endosomal pH

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20713706

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