MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion
about
miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in miceBMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interactionPharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia proteinProtein kinase C iota: human oncogene, prognostic marker and therapeutic targetKnockout of ERK5 causes multiple defects in placental and embryonic developmentTargeting RTK Signaling Pathways in CancerMEK5/ERK5 pathway: the first fifteen yearsX-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific InhibitorDifferential role of MEK5alpha and MEK5beta in BMK1/ERK5 activationBiochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decadeTargeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayActivation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's diseaseCanonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complexThe direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.Role of p90(RSK) in regulating the Crabtree effect: implications for cancer.Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)MEK and the inhibitors: from bench to bedside.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer.Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.ERK5 signalling in prostate cancer promotes an invasive phenotype.Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BBA kinase shRNA screen links LATS2 and the pRB tumor suppressorMEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesisERK5 pathway regulates transcription factors important for monocytic differentiation of human myeloid leukemia cells.Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinomaMitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese populationTargeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants.MEK5 overexpression is associated with the occurrence and development of colorectal cancerRelevance of atypical protein kinase C isotypes to the drug discovery process.The novel lupus antigen related protein acheron enhances the development of human breast cancer.Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathwayAberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation.Phosphorylation of BMK1 induces prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle.Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L.Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancerMitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancerActivation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC).A comparison of epithelial-to-mesenchymal transition and re-epithelializationErk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis.
P2860
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P2860
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@ast
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@en
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@nl
type
label
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@ast
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@en
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@nl
prefLabel
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@ast
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@en
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@nl
P2093
P3181
P356
P1433
P1476
MEK5 overexpression is associa ...... MMP-9 expression and invasion
@en
P2093
P2888
P304
P3181
P356
10.1038/SJ.ONC.1206154
P407
P577
2003-03-01T00:00:00Z
P5875
P6179
1029773545