The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif
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Function, regulation and pathological roles of the Gab/DOS docking proteinsEfficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifNovel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich regionExpression, refolding and crystallizations of the Grb2-like (GADS) C-terminal SH3 domain complexed with a SLP-76 motif peptideSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerA single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domainsGAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signalingInduced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Evolution of SH2 domains and phosphotyrosine signalling networksRegulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complexCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaDiverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domainUCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drugRAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumorsStimulation of hTAFII68 (NTD)-mediated transactivation by v-SrcDirected discovery of bivalent peptide ligands to an SH3 domainGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screenApplication of ring-closing metathesis to Grb2 SH3 domain-binding peptides.HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interactionSpecificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transductionVersatile retargeting of SH3 domain binding by modification of non-conserved loop residues.Titin as a giant scaffold for integrating stress and Src homology domain 3-mediated signaling pathways: the clustering of novel overlap ligand motifs in the elastic PEVK segment.Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pitsTransactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain.Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cellsThe role of Gads in hematopoietic cell signalling.MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlDistinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.
P2860
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P2860
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@ast
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@en
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@nl
type
label
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@ast
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@en
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@nl
prefLabel
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@ast
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@en
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@nl
P2093
P2860
P3181
P356
P1433
P1476
The C-terminal SH3 domain of t ...... SH3-typical P-x-x-P core motif
@en
P2093
C Kardinal
E K Schmidt
M Lewitzky
N H Gehring
S M Feller
U Schaeper
W Birchmeier
P2860
P2888
P304
P3181
P356
10.1038/SJ.ONC.1204202
P407
P577
2001-03-01T00:00:00Z
P5875
P6179
1050721812