Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts
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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorPhosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivoIdentification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transductionMona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development.Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation.Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cellsTyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsThe Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseA RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRCNeph1 cooperates with nephrin to transduce a signal that induces actin polymerizationRegulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynaminBiochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP.Specificity and affinity motifs for Grb2 SH2-ligand interactionsPositive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signalingBoth src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors.Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseThe role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophagesPhorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage eventsThe phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807.Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of ShcThr38 and Ser198 are Pto autophosphorylation sites required for the AvrPto-Pto-mediated hypersensitive response.Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts.The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function.Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophagesDifferential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation.DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophagesDifferent pathways of colony-stimulating factor 1 degradation in macrophage populations revealed by wortmannin sensitivity.A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.CSF-1-induced Src signaling can instruct monocytic lineage choice.
P2860
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P2860
Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts
description
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1993
@ast
im Dezember 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/12/15)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/12/15)
@nl
наукова стаття, опублікована в грудні 1993
@uk
مقالة علمية (نشرت في 15-12-1993)
@ar
name
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@ast
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@en
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@nl
type
label
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@ast
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@en
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@nl
prefLabel
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@ast
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@en
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@nl
P2860
P1433
P1476
Mutation of Tyr697, a GRB2-bin ...... expressed in Rat-2 fibroblasts
@en
P2093
P van der Geer
P2860
P304
P407
P577
1993-12-01T00:00:00Z