Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
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Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationGTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitPhosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationIdentification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gammaHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorMeasurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisalActivation of Src family kinases by colony stimulating factor-1, and their association with its receptorIdentification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinasesThe 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase SypAlpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testesThe N-terminal region of GAP regulates cytoskeletal structure and cell adhesionTwo signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinaseBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayStructure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinaseThe SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signallingInteraction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changesSH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeStructural and functional studies on platelet-derived growth factorThe SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatmentThe SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptorsTyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activationGenetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificityDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaMutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesPhosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteinsNck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cellsBinding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides.The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion.Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP.Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues.RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology.A critical role for PDGFRα signaling in medial nasal process development.A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site.
P2860
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P2860
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
description
1992 nî lūn-bûn
@nan
1992 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@ast
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en-gb
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@nl
type
label
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@ast
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en-gb
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@nl
prefLabel
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@ast
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en-gb
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@nl
P2093
P2860
P921
P1433
P1476
Phosphorylation sites in the P ...... ing GAP and PI3 kinase in vivo
@en
P2093
A Kashishian
A Kazlauskas
J A Cooper
P2860
P304
P407
P577
1992-04-01T00:00:00Z