Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
about
MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylationMolecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesisFlipping of alkylated DNA damage bridges base and nucleotide excision repairNuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsMsh-2 suppresses in vivo mutation in a gene dose and lesion dependent mannerExpression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamideMlh1 deficiency enhances several phenotypes of Apc(Min)/+ miceKRAS mutations in colorectal cancer from Tunisia: relationships with clinicopathologic variables and data on TP53 mutations and microsatellite instability.Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanineProteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repairA new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto RicoLoss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Targeting and processing of site-specific DNA interstrand crosslinks.Out, out, brief candle! Oxidative stress response and life-span.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressRepair of endogenous DNA base lesions modulate lifespan in miceNitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53.A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.Mismatch repair in correction of replication errors and processing of DNA damage.hMutSbeta is required for the recognition and uncoupling of psoralen interstrand cross-links in vitroO6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Embryo toxicity and teratogenicity of formaldehyde.Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.Mismatch repair causes the dynamic release of an essential DNA polymerase from the replication forkDNA repair mechanisms in dividing and non-dividing cells.Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.Aberrant crypt foci as microscopic precursors of colorectal cancer.Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival
P2860
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P2860
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@ast
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@en
type
label
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@ast
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@en
prefLabel
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@ast
Role of DNA mismatch repair an ...... poptosis by alkylating agents.
@en
P2860
P356
P1476
Role of DNA mismatch repair an ...... apoptosis by alkylating agents
@en
P2093
L D Samson
P2860
P304
10764-10769
P356
10.1073/PNAS.96.19.10764
P407
P577
1999-09-01T00:00:00Z