Identification of a specific inhibitor of the dishevelled PDZ domain.
about
The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signalingWnt/beta-catenin signaling and small molecule inhibitorsPDZ domains and their binding partners: structure, specificity, and modificationWnt/beta-catenin signaling: components, mechanisms, and diseasesWnt Signaling in Cancer Stem Cell BiologyTargeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapyDevelopment of anticancer agents targeting the Wnt/β-catenin signalingFlavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapiesWnt signalling in smooth muscle cells and its role in cardiovascular disordersTargeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunitySulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein DishevelledInhibition of oncogenic Wnt signaling through direct targeting of -cateninWnt Drug Discovery: Weaving Through the Screens, Patents and Clinical TrialsIdentification of transmembrane protein 88 (TMEM88) as a dishevelled-binding proteinWnt/β-catenin signalling in prostate cancerTherapeutic use of PDZ protein-protein interaction antagonismThe role of flexibility and conformational selection in the binding promiscuity of PDZ domainsSmall-molecule synergist of the Wnt/beta-catenin signaling pathway.Liposomal packaging generates Wnt protein with in vivo biological activityHighly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells.The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.Inhibition of canonical WNT signaling attenuates human leiomyoma cell growthIdentification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.Postgenomic technologies targeting the Wnt signaling network.An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studiesSynthesis of novel inhibitors blocking Wnt signaling downstream of β-catenin.The Wnt signaling pathway: implications for therapy in osteosarcoma.Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer.Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective.Can we safely target the WNT pathway?Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells.UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs)The schizophrenic faces of PICK1.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in FrizzledConformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
P2860
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P2860
Identification of a specific inhibitor of the dishevelled PDZ domain.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Identification of a specific inhibitor of the dishevelled PDZ domain.
@ast
Identification of a specific inhibitor of the dishevelled PDZ domain.
@en
type
label
Identification of a specific inhibitor of the dishevelled PDZ domain.
@ast
Identification of a specific inhibitor of the dishevelled PDZ domain.
@en
prefLabel
Identification of a specific inhibitor of the dishevelled PDZ domain.
@ast
Identification of a specific inhibitor of the dishevelled PDZ domain.
@en
P356
P1433
P1476
Identification of a specific inhibitor of the dishevelled PDZ domain.
@en
P2093
Jufang Shan
P304
15495-15503
P356
10.1021/BI0512602
P407
P577
2005-11-01T00:00:00Z