The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. - Wikidata - thesis-toulmin - TriplyDB

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

http://www.wikidata.org/entity/Q33505762

about

Wnt/beta-catenin signaling and small molecule inhibitors A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction Targeting the Wnt pathways for therapies Wnt signalling in smooth muscle cells and its role in cardiovascular disorders Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28 Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells Cyclosporin A induces cardiac differentiation but inhibits hemato-endothelial differentiation of P19 cells Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials Wnt/β-catenin signalling in prostate cancer Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.Drug repositioning: a machine-learning approach through data integration.Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth Development of small molecules targeting the Wnt pathway for the treatment of colon cancer: a high-throughput screening approach.Postgenomic technologies targeting the Wnt signaling network.An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS).Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Small molecule modulators of Wnt/β-catenin signaling.Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production Wnt pathway in atypical teratoid rhabdoid tumors.Crohn's disease-derived monocytes fail to induce Paneth cell defensins Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.Dvl3 translocates IPMK to the cell membrane in response to Wnt.Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice.Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes.

P2860

Q24597197-8D0F5CEC-B915-4016-A724-41127DFF008A Q26739665-A2E9251F-A555-4431-B0D1-55CD3940BD6C Q26743403-CAAB0CCF-3AC7-46E8-A3D9-5EC22657F834 Q26821978-19907329-41DD-45C8-BA51-867FBD13EF7B Q26849336-B6A14975-7991-4F75-A658-584D81A32DE9 Q26991723-97911A7D-8398-4DB1-B862-B1DB30A83677 Q27013612-E629A885-2B57-4D42-815E-A6E566FA8A71 Q27316115-5503469F-9004-47B8-A91D-4FE8A27FF994 Q28078703-7417BD97-F069-4293-9D39-29B308731CBB Q28269116-3FB84C4B-E03D-4157-ADBE-51A1426E4517 Q28359714-8D3A7E40-E393-41DF-8C49-36ABC25C3745 Q28478466-F3A52F98-BB79-4CAA-8330-4A8B3E874270 Q28484821-A81C09F1-D374-45CB-8057-EC6CC288BAA7 Q28533608-366A7A7E-9F63-454D-9639-A696D7BBF7C4 Q30275354-3783BF91-9D98-4E69-BA61-6927219CB731 Q30651571-22F09889-2E5E-4825-BC43-14BB4D683DD1 Q33560729-411EA9E0-EC69-4479-A168-284B83EABDFB Q33589705-572CCE21-4EFF-4A7E-AF2D-822E472F846D Q33838680-5590C4B5-0819-4978-B4A6-54B5CA333900 Q33843109-6D7B507E-EA11-4922-90D4-14B8D03D80AB Q33961380-6D32D152-B575-4DA8-9322-8CC18C8D007B Q34199032-474D6287-ADEE-4767-B45E-B0AEDAE24986 Q34604768-E707CCF8-0E14-4464-9F49-9947B2D14EAE Q34988375-FBE78C49-A662-40D7-890A-4D495BF69D4D Q35051128-E30BB5EB-3D84-4D65-B20D-F202FC04823B Q35133487-D902023B-BCC3-47C8-A2C1-18D1582DE7B3 Q35174240-370202FA-3BB1-480E-BB90-C85088EBAC12 Q35251049-10866518-FCA7-4E56-8940-8A74026CB9A8 Q35664315-02DAB0D9-7060-4645-BB7F-A95475E9B5E4 Q35788801-BD5B1E22-527A-4CD3-ADF9-CD46AC3D0AEB Q35825462-82E2CC5E-940C-4F29-8B91-688693527E75 Q35869295-8150A713-DC35-4708-8079-46258CA2DA77 Q35906885-BDFB0C1C-201E-4E4F-B43C-A20BFECF8B09 Q36335790-B84EF348-C9FB-451B-88A7-7711AB78A7CE Q36351495-4C74C76E-6059-4EDE-971B-9E17B6B59F2F Q36454906-79EB39DA-92EE-405E-A9B1-02E7C73214DA Q36515479-8B34C000-9198-4C1A-84B8-3B1841AB1BC5 Q36544147-35952DEA-581B-47BF-8903-09C2F70C7CA9 Q36583420-E69900A5-6556-4A40-9127-DDE1CB9D9C55 Q37098895-5AE0C724-760B-466D-8607-37D1AF26CB70

P2860

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

http://www.wikidata.org/entity/Q33505762

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年学术文章

@wuu

2009年学术文章

@zh-cn

2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

name

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@ast

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@en

type

label

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@ast

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@en

prefLabel

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@ast

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

@en

P1433

Q33505762-4FA39B93-72FC-47AD-BADB-EE9D86D82797

P1476

Q33505762-C7E31A3C-2CE3-4107-BFCA-DA0F906B1B80

P2093

Q33505762-3E3E3156-5906-4EA0-AE9B-1007DB7BF0AF

Q33505762-3E60592D-03FE-4EA8-B2DE-35C377CB354B

Q33505762-888A806A-4666-425C-B2E6-C2C9D9202354

Q33505762-89D24E97-3A67-4020-9A22-3106019A477A

Q33505762-955D26C9-108F-4541-B3E8-C6A4BB13B271

Q33505762-CDFB5071-C2D1-4078-864B-D03CFF18F275

Q33505762-EE698D89-0BB3-40CD-8083-1BA2C0A57BBE

P2860

Q33505762-03E2422D-7677-4633-8C3D-91D39202A859

Q33505762-0A047DB0-EBA7-460A-B7BA-64CD9A85DDE8

Q33505762-100716E0-260C-4D6F-A3A8-2359E7445708

Q33505762-1253115A-C141-496C-901E-153B02B57749

Q33505762-15E3DE76-F69F-49C1-80F7-EBBBFE07452C

Q33505762-3FD5AF9F-925A-425B-BA8D-19C2455775DE

Q33505762-43557442-BCFE-4337-98E5-801B32560876

Q33505762-495A7FBA-1E28-4384-A4D4-326D696113BA

Q33505762-541059C7-8B3C-484A-BCBE-272E01B2D224

Q33505762-5D18CF0B-5339-4F35-B591-4620945E232C

P304

Q33505762-E952D64E-5105-4848-B918-AA288C16D765

P31

Q33505762-89C6B747-240E-412E-AE2C-0F37D360E251

P356

Q33505762-FDC3E148-AEF0-49C0-83CB-34F6840F0D8B

P407

Q33505762-A811C3E0-0B13-4F52-BB5B-D2CA17058499

P433

Q33505762-7BF952C0-52CA-4F3B-9F27-2AEE888E6FA2

P478

Q33505762-41438638-D6A9-4E60-9522-AB1B84426E8E

P50

Q33505762-370F284C-29F2-4133-A580-B24C89282471

P577

Q33505762-F1062EBD-F976-4304-85EB-97EF948B432E

P5875

Q33505762-7F638C4A-964D-4C89-A9DC-45A5A4499338

P698

Q33505762-C0EC606A-69D3-4B65-A357-435AFE666903

P932

Q33505762-FDECFFDC-5FC0-476E-9672-40578B5A3059

P356

P1433

P1476

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling

@en

P2093

Jiangbo Wang

http://www.w3.org/2001/XMLSchema#string

Jiuyi Lu

http://www.w3.org/2001/XMLSchema#string

Larry S Barak

http://www.w3.org/2001/XMLSchema#string

Michael C Bond

http://www.w3.org/2001/XMLSchema#string

Minyong Chen

http://www.w3.org/2001/XMLSchema#string

Wei Chen

http://www.w3.org/2001/XMLSchema#string

Xiu-Rong Ren

http://www.w3.org/2001/XMLSchema#string

P2860

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Mechanism of action of reagents that uncouple oxidative phosphorylation

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer

WNT and beta-catenin signalling: diseases and therapies

Endocytosis and molecular sorting

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

Synthetic small molecules that control stem cell fate

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.

Identification of a specific inhibitor of the dishevelled PDZ domain.

P304

10267-10274

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/BI9009677

http://www.w3.org/2001/XMLSchema#string

P407

P433

43

http://www.w3.org/2001/XMLSchema#string

P478

48

http://www.w3.org/2001/XMLSchema#string

P50

Herbert Kim Lyerly

P577

2009-11-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

26829704

http://www.w3.org/2001/XMLSchema#string

P698

19772353

http://www.w3.org/2001/XMLSchema#string

P932

2801776

http://www.w3.org/2001/XMLSchema#string