Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. - Wikidata - thesis-toulmin - TriplyDB

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.

http://www.wikidata.org/entity/Q33303185

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RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response Five dysfunctional telomeres predict onset of senescence in human cells Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes POT1 association with TRF2 regulates telomere length Finding the end: recruitment of telomerase to telomeres TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo Telomeres in aging and disease: lessons from zebrafish Telomere- and Telomerase-Associated Proteins and Their Functions in the Plant Cell Multiple facets of TPP1 in telomere maintenance A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians Telomeres avoid end detection by severing the checkpoint signal transduction pathway ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres DNA-damage response and repair activities at uncapped telomeres depend on RNF8 SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation How telomeres solve the end-protection problem.TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.Distinct functions of POT1 at telomeres.Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita TOR regulates cell death induced by telomere dysfunction in budding yeast.Multiple roles for MRE11 at uncapped telomeres.Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer Characterization of oxidative guanine damage and repair in mammalian telomeres.Pot1 and telomere maintenance.The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.Protection and replication of telomeres in fission yeast.Zebrafish as a model system to study the physiological function of telomeric protein TPP1 ATR contributes to telomere maintenance in human cells PRL-3 promotes telomere deprotection and chromosomal instability.Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.

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Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.

http://www.wikidata.org/entity/Q33303185

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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SJ.EMBOJ.7601893

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The EMBO Journal

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Dysfunctional telomeres activa ...... nse to suppress tumorigenesis.

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Eric J Brown

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Guohua Yuan

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Hua He

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Sandy Chang

http://www.w3.org/2001/XMLSchema#string

Suzanne Chan

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Wilfredo Cosme-Blanco

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Xiaolan Guo

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Yahong Lin

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Yibin Deng

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P2860

Mammalian telomeres end in a large duplex loop

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

The POT1-TPP1 telomere complex is a telomerase processivity factor

PTOP interacts with POT1 and regulates its localization to telomeres

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

Telomere protection by mammalian Pot1 requires interaction with Tpp1

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