Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. - Wikidata - thesis-toulmin - TriplyDB

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

http://www.wikidata.org/entity/Q33412998

about

Redox homeostasis in pancreatic β cells Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion Mitochondrial proton and electron leaks Redox regulation of mitochondrial function Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species Insulin signaling regulates mitochondrial function in pancreatic beta-cells Autoregulation of free radicals via uncoupling protein control in pancreatic beta-cell mitochondria.Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes Glucolipotoxicity of the pancreatic beta cell.ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity Uncoupling protein-2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS-1E cells and in diabetic mouse islets.Regulation of insulin secretion: role of mitochondrial signalling.The regulation and turnover of mitochondrial uncoupling proteins.Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation.Mitochondrial uncoupling and lifespan.The on-off switches of the mitochondrial uncoupling proteins.Deletion of mitochondrial uncoupling protein-2 increases ischemic brain damage after transient focal ischemia by altering gene expression patterns and enhancing inflammatory cytokines Pancreatic function in carboxyl-ester lipase knockout mice High passage MIN6 cells have impaired insulin secretion with impaired glucose and lipid oxidation.Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366)Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts.UCP2 knockout suppresses mouse skin carcinogenesis.A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.Acute stimulation of white adipocyte respiration by PKA-induced lipolysis Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells.By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+.The role of mitochondria in the pathogenesis of type 2 diabetes UCP2 Modulates Cardioprotective Effects of Ru360 in Isolated Cardiomyocytes during Ischemia Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains.Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage.Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome.Expression profiling analysis: Uncoupling protein 2 deficiency improves hepatic glucose, lipid profiles and insulin sensitivity in high-fat diet-fed mice by modulating expression of genes in peroxisome proliferator-activated receptor signaling pathw UCP2 regulates the glucagon response to fasting and starvation The role of uncoupling proteins in diabetes mellitus Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.

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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.

http://www.wikidata.org/entity/Q33412998

description

2009 nî lūn-bûn

@nan

2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Persistent oxidative stress du ...... pancreatic beta-cell function.

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Persistent oxidative stress du ...... pancreatic beta-cell function.

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Persistent oxidative stress du ...... pancreatic beta-cell function.

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Persistent oxidative stress du ...... pancreatic beta-cell function.

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Persistent oxidative stress du ...... pancreatic beta-cell function.

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Persistent oxidative stress du ...... pancreatic beta-cell function.

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Diane Edelstein

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Kiefer W Daniel

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Michael Brownlee

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Otis Lyght

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Sheila Collins

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Yushi Bai

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P2860

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Uncoupling proteins: current status and therapeutic prospects

Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production

Free radicals in the physiological control of cell function

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets

Markers of mouse macrophage development detected by monoclonal antibodies

Peroxynitrite reactions and formation in mitochondria

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

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10.1210/EN.2008-1642

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7

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150

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Barbara E Corkey

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24043787

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