The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseStructural basis of open channel block in a prokaryotic pentameric ligand-gated ion channelMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Neuronal nicotinic receptors: from protein structure to functionThe atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channelsCyanotriphenylborate: subtype-specific blocker of glycine receptor chloride channelsPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function.Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation.Homologous mutations on different subunits cause unequal but additive effects on n-alcohol block in the nicotinic receptor poreStructural effects of quinacrine binding in the open channel of the acetylcholine receptor.The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.Are Caenorhabditis elegans receptors useful targets for drug discovery: pharmacological comparison of tyramine receptors with high identity from C. elegans (TYRA-2) and Brugia malayi (Bm4).The pharmacological profile of ELIC, a prokaryotic GABA-gated receptorThree-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction.Block of potassium currents in rat isolated sympathetic neurones by tricyclic antidepressants and structurally related compounds.Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action.State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit.Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 regionDelimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazineIdentifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.Distinctions in ligand binding sites on the nicotinic acetylcholine receptor.Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia.Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!Cys-loop receptor channel blockers also block GLIC.Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.The transmembrane domains of the nicotinic acetylcholine receptor contain alpha-helical and beta structures[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.Agonist self-inhibitory binding site of the nicotinic acetylcholine receptor.Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effectorLuminal and non-luminal non-competitive inhibitor binding sites on the nicotinic acetylcholine receptor.Assigning functions to residues in the acetylcholine receptor channel region (review).Alpha 4-2 beta 2 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugsProbing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor.Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.Structure of the pore-forming transmembrane domain of a ligand-gated ion channel.
P2860
Q24618824-2F62BB80-4B3D-4BD0-B044-366CCCB40B2AQ27665499-80FD2A79-891C-4D7B-912C-B3277BE1A525Q27676065-A05357F4-3B1D-4A4E-945D-BCB6400E70EDQ28214998-E844D87B-98CD-478E-87DD-5F2B771A98A3Q28316466-FDD53D8A-517D-49C5-8944-DCA8BA83994DQ28369450-F47D0D68-1940-469A-9012-615B8F747E01Q30402002-D49F049F-13C4-471F-9AAE-69ABA9DF58C2Q30416781-8561D757-CAB6-41B5-89CA-470B5BE5DF40Q30574129-659EE3EF-850B-4CBB-8CC6-4A84AE08074DQ33915437-A69F0817-0207-407C-97E6-93A8931B8610Q34918704-2F88C760-D2A1-4E45-84CD-5AF69FB7CE7DQ35205566-78248422-6299-4119-82B5-E90EDAAE37E7Q36196893-ABCF4831-9302-4EAB-981B-75B1610A1128Q36199211-983BE583-1934-4752-B806-E6A4EE45B1A3Q36224077-0C5F3012-84BA-4ED3-A8FB-3F51E6B833AAQ36329923-7674866A-8327-439B-A6AE-F46CD391DF8EQ36396119-3988E849-527E-48EE-B348-140E95A047DAQ36412074-F2BFFB93-73E9-4795-97CB-E47ACA97A03DQ36415600-14C0D099-E61B-44B0-B6E0-6337A636C125Q36436171-B6212B6C-6757-4CF0-9123-A84D8621E3EFQ36443394-8E8DD5D1-7AB1-4DE5-9EA5-DC21A824A1C4Q36830063-51654F58-2483-46F4-BC06-C576986C2E73Q37379919-109A9CD1-9D83-4FC2-AADE-D6A627185235Q37708111-8FED8EC1-A191-48E4-8558-A7913561ADE0Q37768676-8FACE8C9-0B65-4FB1-B939-13A97CE2E2CEQ38066550-D9F3472D-FCBF-4C2F-AF8F-0D38B42ABF0CQ38155454-57D6B4AA-3DB0-403F-A0C2-5E7E4A19C8E6Q39949261-7BAB879C-DCE5-44EB-A339-3EC6111137B8Q40113363-491A23D0-9D91-4BAD-93E0-68F907CBE131Q40287359-50CBAB72-112F-486E-B4F7-62809A1F5DB5Q40790572-C2C3AC08-FFE0-4E37-9EF9-B3FBD88A3F90Q40818014-2B7674D4-3E33-49F5-8978-442578AD9F1FQ41045514-ED290A80-315F-43D5-A3C3-5ECD755C60E4Q41262378-C5899CCE-7087-42B9-8F2E-1C5E20F2C25FQ41468173-3813BC7F-37F9-46B1-98E0-BDA9B9F65EABQ41716127-86ACC44A-5013-4728-980A-935F79D367EDQ41883407-E157F86C-6A04-439E-BC25-032ADF80E193Q42081252-6CAFE3E6-AEE8-42A4-B49D-D7D3D62CECE0Q42616990-29692510-E3D4-4E19-8A80-C4C031C4398DQ43592361-2A7F0516-4D84-4E67-BBA7-F13F8AF18C25
P2860
The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel.
description
1990 nî lūn-bûn
@nan
1990 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
The noncompetitive blocker [3H ...... structure of the ion channel.
@ast
The noncompetitive blocker [3H ...... structure of the ion channel.
@en
type
label
The noncompetitive blocker [3H ...... structure of the ion channel.
@ast
The noncompetitive blocker [3H ...... structure of the ion channel.
@en
prefLabel
The noncompetitive blocker [3H ...... structure of the ion channel.
@ast
The noncompetitive blocker [3H ...... structure of the ion channel.
@en
P2093
P2860
P356
P1476
The noncompetitive blocker [3H ...... structure of the ion channel.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.12.4675
P407
P577
1990-06-01T00:00:00Z