Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.
about
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwayP-Rex2, a new guanine-nucleotide exchange factor for RacCrucial structural role for the PH and C1 domains of the Vav1 exchange factorOligomerization of DH domain is essential for Dbl-induced transformationAn effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machineThe integrin-actin connection, an eternal love affairVav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancerPhosphoinositides: tiny lipids with giant impact on cell regulationStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor IntersectinStructural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica PathogenesisThe BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAPRegulation of proto-Dbl by intracellular membrane targeting and protein stabilityPositive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cellsThe C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipidsCharacterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesisAn active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligandRegulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.Structural determinants for the biological activity of Vav proteins.Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterpartsSubstrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis.The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.Rho proteins, PI 3-kinases, and monocyte/macrophage motility.The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.A mathematical model of CR3/TLR2 crosstalk in the context of Francisella tularensis infection.Intramolecular interactions between the Dbl homology (DH) domain and the carboxyl-terminal region of myosin II-interacting guanine nucleotide exchange factor (MyoGEF) act as an autoinhibitory mechanism for the regulation of MyoGEF functions.Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.Up-regulation of ECT2 is associated with poor prognosis in gastric cancer patients.
P2860
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P2860
Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@ast
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@en
type
label
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@ast
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@en
prefLabel
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@ast
Control of intramolecular inte ...... nd Sos1 regulates Rac binding.
@en
P2093
P2860
P356
P1476
Control of intramolecular inte ...... and Sos1 regulates Rac binding
@en
P2093
P2860
P304
15074-15081
P356
10.1074/JBC.M907269199
P407
P577
2000-05-01T00:00:00Z