Use of the nuclear receptor PXR to predict drug interactions.
about
Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalaciaSustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor ActivationCrystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonismIdentification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesEnhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alphaAlterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactionsThe phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptorInteractions that determine the assembly of a retinoid X receptor/corepressor complex.Population pharmacokinetic modeling of the association between 63396C->T pregnane X receptor polymorphism and unboosted atazanavir clearance.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.High-throughput screening approaches for investigating drug metabolism and pharmacokinetics.Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).Tissue-specific regulation of pregnane X receptor in cancer development and therapy.Cell-based systems to assess nuclear receptor activation and their use in drug development.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesDrug-activated nuclear receptors CAR and PXR.Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients.RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function.Functional evolution of the pregnane X receptor.PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.PXR antagonists and implication in drug metabolism.Genomic profiling in nuclear receptor-mediated toxicity.Structural basis of human pregnane X receptor activation by the hops constituent colupuloneFunctional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio)Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.Personalization of dexamethasone therapy in childhood acute lymphoblastic leukaemia.BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.Attenuating pregnane X receptor (PXR) activation: a molecular modelling approach.A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.Effect of quercetin on CYP3A activity in Chinese healthy participants.Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues.Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine.Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts.
P2860
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P2860
Use of the nuclear receptor PXR to predict drug interactions.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Use of the nuclear receptor PXR to predict drug interactions.
@ast
Use of the nuclear receptor PXR to predict drug interactions.
@en
Use of the nuclear receptor PXR to predict drug interactions.
@nl
type
label
Use of the nuclear receptor PXR to predict drug interactions.
@ast
Use of the nuclear receptor PXR to predict drug interactions.
@en
Use of the nuclear receptor PXR to predict drug interactions.
@nl
prefLabel
Use of the nuclear receptor PXR to predict drug interactions.
@ast
Use of the nuclear receptor PXR to predict drug interactions.
@en
Use of the nuclear receptor PXR to predict drug interactions.
@nl
P1433
P1476
Use of the nuclear receptor PXR to predict drug interactions.
@en
P2093
P356
10.1016/S0300-483X(00)00300-0
P407
P577
2000-11-01T00:00:00Z