In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells - Wikidata - thesis-toulmin - TriplyDB

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

http://www.wikidata.org/entity/Q34322594

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α-Synuclein as an intrinsically disordered monomer--fact or artefact?α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Biophysical characterization of α-synuclein and its controversial structure Exploring the accessible conformations of N-terminal acetylated α-synuclein The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease Seeking a mechanism for the toxicity of oligomeric α-synuclein Characterization of α-Synuclein Multimer Stoichiometry in Complex Biological Samples by Electrophoresis α-Synuclein mutations cluster around a putative protein loop.The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.A pipeline for determining protein-protein interactions and proximities in the cellular milieu Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.Mitochondria-associated endoplasmic reticulum membrane (MAM) regulates steroidogenic activity via steroidogenic acute regulatory protein (StAR)-voltage-dependent anion channel 2 (VDAC2) interaction A new method for quantitative immunoblotting of endogenous α-synuclein.Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Molecular details of α-synuclein membrane association revealed by neutrons and photons.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation The Interplay between Alpha-Synuclein Clearance and Spreading Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules ExPLAining early synucleinopathies.An Outer Mitochondrial Translocase, Tom22, Is Crucial for Inner Mitochondrial Steroidogenic Regulation in Adrenal and Gonadal Tissues.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.Poststroke Induction of α-Synuclein Mediates Ischemic Brain Damage.Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.Evidence of native α-synuclein conformers in the human brain.The function of α-synuclein.

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In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells

http://www.wikidata.org/entity/Q34322594

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013年の論文

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In vivo cross-linking reveals ...... n neurons and non-neural cells

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In vivo cross-linking reveals ...... n neurons and non-neural cells

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In vivo cross-linking reveals ...... n neurons and non-neural cells

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In vivo cross-linking reveals ...... n neurons and non-neural cells

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JBC.M112.403311

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Journal of Biological Chemistry

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In vivo cross-linking reveals ...... n neurons and non-neural cells

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Andrew J Newman

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Dennis Selkoe

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Eric S Luth

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Tim Bartels

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Ulf Dettmer

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P2860

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells

Self-association of the molecular chaperone HSC70

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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