Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. - Wikidata - thesis-toulmin - TriplyDB

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

http://www.wikidata.org/entity/Q34622632

about

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Ubiquitin modifications Myosins, Actin and Autophagy Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy A Mechanistic Review of Mitophagy and Its Role in Protection against Alcoholic Liver Disease Expanding the ubiquitin code through post-translational modification Hypoxia signaling pathways: modulators of oxygen-related organelles Quantifying ubiquitin signaling The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications Parkin structure and function Pathologic and therapeutic implications for the cell biology of parkin Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering Activation of the E3 ubiquitin ligase Parkin.Sending Out an SOS: Mitochondria as a Signaling Hub Targeting Pink1-Parkin-mediated mitophagy for treating liver injury Mitochondrial dynamics and viral infections: A close nexus Autophagosome dynamics in neurodegeneration at a glance Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation Structural insights into Parkin substrate lysine targeting from minimal Miro substrates Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation.Quantitative proteomic analysis of Parkin substrates in Drosophila neurons.The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system Mitophagy and cancer.A polyubiquitin chain reaction: parkin recruitment to damaged mitochondria Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy.Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy A Ubl/ubiquitin switch in the activation of Parkin Ubiquitin-Dependent Modification of Skeletal Muscle by the Parasitic Nematode, Trichinella spiralis Using protein motion to read, write, and erase ubiquitin signals.

P2860

Q24310659-BA3171C2-9CDB-46AE-BF5E-8BE08F34C7AA Q24310717-79DFD302-3C04-4987-980A-3277CDD2F6CC Q26751380-FA00F5E1-BC91-4E2B-A409-7D33C892A359 Q26752776-19C447FE-4B8E-4D4A-9F8C-92F268D75894 Q26770342-DFB639B2-95BB-44E3-BE67-8F409E16445F Q26776469-745B40FF-6B04-4826-BC3A-FDA50B819BAE Q26778940-AF4BB972-A907-4D54-9344-3CE7F7D73327 Q26798369-ADF0E32D-FF96-4C84-89B0-CB4AB5F70D88 Q26799950-C589FB05-CEF0-4F3A-A16D-73BE3FFD8EAB Q26823466-2A29F524-B161-48E3-A3BB-58A16C689C89 Q26853492-E590758A-A924-4CB8-B8C4-B7CBA9251250 Q26995496-4C66B144-E6B5-4A63-A59D-F29C42E95334 Q27010567-ECAFC604-8169-490C-825B-ACBC6ECD3ED7 Q27011353-6762A290-6705-4A4A-B2D7-7335DD1410E3 Q27305291-A6DC20A8-E45E-45C0-A9F7-F61CA5C8A30C Q27311602-360C6BC0-5B6B-449F-9C37-697B298382CA Q27334072-2EA585A0-92C4-45AE-98C6-26D83A51F8CC Q28073077-571630F9-D367-4155-BD39-25FA492949A5 Q28082937-EC9EF7C1-95B8-4999-8C0F-61A4589FD761 Q28083493-7158DC5E-0A0E-447C-B80C-A33D84FA65CE Q28084804-DE4F1C74-8656-4312-AD45-5FBD479D3180 Q28393192-5A69C653-C0FD-4813-9768-5CFEA110D11B Q28830194-E062AC24-2882-4BE7-85EB-F3E37CECC04C Q28831032-C01AB185-3ED4-4AA6-A096-47F8C51FAF0D Q30677261-D924C748-D77F-4EB2-8956-A07F89A3E8BD Q30844860-3C47B421-6144-49A5-B458-806A71DF1910 Q30846938-7D361B5D-19C0-4B13-AFFF-8296439258E7 Q33628850-8D227AFA-B6E4-4360-AC0F-8D8E3A0E1054 Q35215652-11D35A0D-9C83-4FF1-8B4D-A3A832297445 Q35547322-2AE3AB8D-BFBE-459E-BF4D-426CBEC6B3F9 Q35669194-95193BEE-D1AF-4646-8357-8E0C10E588FD Q35888058-E93816D2-CB09-4A98-9F6A-D73DF9AE94DD Q35899904-DB575A27-8494-4C09-A421-D61FB6D5A388 Q35947378-0C129556-B8F8-43C3-A9C7-87FA540A2F86 Q36062419-70555FA1-37E9-4DC9-AF57-B5291AE10A24 Q36078552-5C8191DF-FA17-4BBB-80B2-E9CF092F72A7 Q36118105-FC6A8571-6CCD-48C9-A54C-4478F4AAEBB6 Q36172257-28A1C038-0104-49C0-8831-8246079E1E1F Q36199860-4539DD62-19E3-4087-B6E2-3EB826D2575E Q36283663-1DEAB806-DFD3-4DD6-91F0-664C4CFC7D6C

P2860

Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis.

http://www.wikidata.org/entity/Q34622632

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@ast

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@en

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@nl

type

label

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@ast

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@en

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@nl

prefLabel

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@ast

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@en

Quantitative proteomics reveal ...... and ubiquitin chain synthesis.

@nl

P1433

Q34622632-5F8FE65D-6727-4EB1-9975-7BAD8362C0A0

P1476

Q34622632-372A73FE-0AD7-46C0-AC48-937A37C09710

P2093

Q34622632-041AA189-59EB-4C01-8110-552AF42B55AB

Q34622632-14565122-0BB3-4409-8B7C-DD20D0A89FFA

Q34622632-309A38F6-82F7-4A89-9BDC-5D9C47DF4A03

Q34622632-3EBE6F93-64E2-4D92-B2C1-80BA689FF1F6

Q34622632-459F6298-FBA2-4436-A1A9-E7523D6785BF

Q34622632-5E9A089C-9B6E-4960-BE3A-C2654D21CBAC

Q34622632-B7FDCEE8-2A11-4F14-962C-9295D3EC433B

Q34622632-D01E428D-50F7-43BF-A2A4-CACEA843632F

P2860

Q34622632-049CDC48-E336-45E0-A94F-0E62725C32CD

Q34622632-07A204CC-501E-47FC-8F28-8FEC7AA08DD9

Q34622632-0D09B77B-A9DD-47A4-AB65-99909929B989

Q34622632-1A26B9B5-3539-4DDB-8DED-4362659F0D71

Q34622632-1AC25AE4-6823-414F-B79A-7CA9A0948056

Q34622632-1F64D351-0216-484C-B695-93C257D8136E

Q34622632-22D41315-1F33-48C9-BD05-A66F5DE8EBFC

Q34622632-2311026A-FD80-4AFE-8261-6EE79B337D30

Q34622632-30F14629-F14F-404F-89E0-78E6B59E5CEC

Q34622632-39B7654E-40C2-4098-8AD0-38E3D1D8BB1A

P304

Q34622632-A6E57B11-A29F-48DF-A97F-2674D2304935

P31

Q34622632-7442C5A2-667E-4318-A224-FD9D7353E992

P356

Q34622632-07E42C3A-810F-4C60-90D0-6DB68B76F5CC

P433

Q34622632-0240D148-0E2A-4EC8-8F04-73FD62D5981B

P478

Q34622632-B10D48F8-5FCC-41B5-A3E7-B9FB7FA3C090

P50

Q34622632-017C5B98-C5F7-47C2-A17E-775906ED9BA6

Q34622632-23C44F38-79DF-447C-834A-A1D2E03C6467

Q34622632-2A0E5640-80D8-4C5D-BDD2-F1D20094E780

Q34622632-575AA7C7-BA95-4C91-BB1E-B43435F69E7A

Q34622632-7FE47A4C-0E6D-4960-801F-DEE196CCD633

Q34622632-DAFB9B71-4268-4A68-91FB-0D80FDFD0C16

P577

Q34622632-4EDAB290-7A33-46C6-B25F-3638FAE4E669

P5875

Q34622632-91DFC62D-7407-44D3-8CEF-2C39C7B0E652

P698

Q34622632-013EE91F-A8F5-4100-B1A8-F60D5641A8DC

P932

Q34622632-8C7EE9F6-7698-413E-B5CB-CF5194425326

P356

J.MOLCEL.2014.09.007

P1433

P1476

Quantitative proteomics reveal ...... and ubiquitin chain synthesis

@en

P2093

David M Duda

http://www.w3.org/2001/XMLSchema#string

James A Wells

http://www.w3.org/2001/XMLSchema#string

James T Koerber

http://www.w3.org/2001/XMLSchema#string

Jennifer L Olszewski

http://www.w3.org/2001/XMLSchema#string

Jin-Mi Heo

http://www.w3.org/2001/XMLSchema#string

Shireen A Sarraf

http://www.w3.org/2001/XMLSchema#string

Tiao Xie

http://www.w3.org/2001/XMLSchema#string

Vladislav O Sviderskiy

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Ubiquitin is phosphorylated by PINK1 to activate parkin

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

Autoregulation of Parkin activity through its ubiquitin-like domain

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

P304

360-375

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1016/J.MOLCEL.2014.09.007

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

56

http://www.w3.org/2001/XMLSchema#string

P50

Jeffrey W. Harper

Brenda A Schulman

Sean A Beausoleil

Mark P Jedrychowski

P577

2014-10-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

266623268

http://www.w3.org/2001/XMLSchema#string

P698

25284222

http://www.w3.org/2001/XMLSchema#string

P932

4254048

http://www.w3.org/2001/XMLSchema#string