Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
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Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathwayProtein degradation pathways in Parkinson's disease: curse or blessingAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersGeneration of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug ScreeningTime course and progression of wild type α-synuclein accumulation in a transgenic mouse model.Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesα-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophyATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.Review: Novel treatment strategies targeting alpha-synuclein in multiple system atrophy as a model of synucleinopathyER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Studying neurodegenerative diseases in culture models.Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism.α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy.The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells.The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease.Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stressMutations in LRRK2 potentiate age-related impairment of autophagic flux.Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy.The neuropathology of multiple system atrophy and its therapeutic implications.Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Multiple system atrophy: experimental models and reality.Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies.Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration.Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.In vitro models of multiple system atrophy from primary cells to induced pluripotent stem cells.
P2860
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P2860
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@ast
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@en
type
label
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@ast
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@en
prefLabel
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@ast
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@en
P2093
P2860
P50
P356
P1433
P1476
Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.
@en
P2093
Anne-Maria Poehler
Jacqueline Schneider
Jochen Klucken
Juergen Winkler
Pamela J McLean
P2860
P304
P356
10.4161/AUTO.19371
P50
P577
2012-05-01T00:00:00Z