Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
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alpha-Synuclein and neuronal cell deathParkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer modelPolo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivoPlk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppressionImpaired c-Fos and polo-like kinase 2 induction in the limbic system of fear-conditioned α-synuclein transgenic miceSelective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brainAlpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical ApplicationThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseRational methods for the selection of diverse screening compoundsRequirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memoryPhosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactionsMammalian target of rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures.Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy.Phosphorylation of synucleins by members of the Polo-like kinase family.Targeting protein kinases in central nervous system disordersAutoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.Polo-box domain: a versatile mediator of polo-like kinase function.Serine 129 phosphorylation reduces the ability of alpha-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson's disease brain tissue by intact protein mass spectrometry.Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.Genetic determinants at the interface of cancer and neurodegenerative disease.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease.SMG1 identified as a regulator of Parkinson's disease-associated alpha-synuclein through siRNA screening.Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivoIdentification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].From Plk1 to Plk5: functional evolution of polo-like kinasesNigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.Characterization of kinases involved in the phosphorylation of aggregated α-synuclein.The Interplay between Alpha-Synuclein Clearance and SpreadingLK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegenerationSuppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra.Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration.A novel multiplex assay for simultaneous quantification of total and S129 phosphorylated human alpha-synuclein.Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization.Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.
P2860
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P2860
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Polo-like kinase 2 (PLK2) phos ...... 129 in central nervous system.
@en
Polo-like kinase 2
@nl
type
label
Polo-like kinase 2 (PLK2) phos ...... 129 in central nervous system.
@en
Polo-like kinase 2
@nl
altLabel
Polo-like Kinase 2 (PLK2) Phos ...... 129 in Central Nervous System
@en
prefLabel
Polo-like kinase 2 (PLK2) phos ...... 129 in central nervous system.
@en
Polo-like kinase 2
@nl
P2093
P2860
P356
P1476
Polo-like kinase 2 (PLK2) phos ...... 129 in central nervous system.
@en
P2093
Carla Ramos
David Chereau
David Chian
Elizabeth F Brigham
Ferdie Soriano
Frederique Bard
Guriqbal S Basi
Irene Griswold-Prenner
Jason M Goldstein
P2860
P304
P356
10.1074/JBC.C800206200
P407
P577
2008-11-12T00:00:00Z